CAJ | 학술논문

目的探讨平原移居高原时间对健康青年男性脑血流动力学参数的影响及其种族差异性.方法随机选取世居平原、从平原地区移居高原4 d、1年和5年的汉族及世居高原的藏族青年作为研究对象,均为健康男性.应用彩色双功能多普勒超声(CDDS)测量双侧椎动脉和颈内动脉的内径及平均血流速度,同步记录心率、血压、血氧饱和度,并检查血红蛋白浓度,以计算全脑血流量(TCBF)、全脑血管阻力(TCVR)及全脑供氧量(TCOS).结果汉族移居高原后,TCVR和TCBF在刚上高原后会有一过性的变化(P<0.05),而后维持在平原水平,且后者明显高于世居藏族(P<0.05);而血压和TCOS则迅速升高(P<0.05),并在相对较长的时间内维持在一个稳定的水平,且始终高于世居藏族(P<0.05).结论汉族移居高原后脑血流在短时间内就能发生适应性变化,并长时间保持在固定的水平,但这种适应能力始终弱于世居高原的藏族.CDDS法可无创测量脑血流量,在高原相关性脑血流动力学的研究中具有重要价值.
목적 탐토평원이거고원시간대건강청년남성뇌혈류동역학삼수적영향급기충족차이성.방법 수궤선취세거평원、종평원지구이거고원4 d、1년화5년적한족급세거고원적장족청년작위연구대상,균위건강남성.응용채색쌍공능다보륵초성(CDDS)측량쌍측추동맥화경내동맥적내경급평균혈류속도,동보기록심솔、혈압、혈양포화도,병검사혈홍단백농도,이계산전뇌혈류량(TCBF)、전뇌혈관조력(TCVR)급전뇌공양량(TCOS).결과 한족이거고원후,TCVR화TCBF재강상고원후회유일과성적변화(P<0.05),이후유지재평원수평,차후자명현고우세거장족(P<0.05);이혈압화TCOS칙신속승고(P<0.05),병재상대교장적시간내유지재일개은정적수평,차시종고우세거장족(P<0.05).결론 한족이거고원후뇌혈류재단시간내취능발생괄응성변화,병장시간보지재고정적수평,단저충괄응능력시종약우세거고원적장족.CDDS법가무창측량뇌혈류량,재고원상관성뇌혈류동역학적연구중구유중요개치.
Objective To study the effects of duration of migration from sea-level to high-altitude on cerebral hemodynamic parameters and their ethnic differences.Methods This randomized comparative study recruited 5 groups of healthy male subjects which were native Hans at sea-level (NHS),Han migrants from sea-level to high-altitude (HMSH,where HMSH-a for residence duration of 4 days,HMSH-b for 1 year,and HMSH-c for 5 years),and native Tibetans at high-altitude (NTH).Color duplex Doppler sonography (CDDS) was used to measure bilateral vertebral and internal carotid arterial diameters,mean flow velocities.The heart rate,arterial blood pressure,and arterial oxygen saturation were also recorded simultaneously,and in combination,hemoglobin was measured to assess total cerebral blood flow (TCBF),total cerebrovascular resistance (TCVR),and total cerebral oxygen supply (TCOS).Results After migration to high-altitude,Hans' TCVR and TCBF maintained the level of NHS after transient changes during early stage (P<0.05),and the TCBF was markedly higher than that of NTH (P<0.05);while the blood pressure and TCOS increased abruptly (P<0.05) at the beginning and kept for a relatively long time at a constant level which were higher than those of NTH all the time (P<0.05).Conclusions Han migrants can acclimate to high-altitude by adaptive change of cerebral blood flow over a short time and maintain a constant adaptability which is always weaker than that of native Tibetans.CDDS can be used for non-invasive measurement of actual cerebral blood flow,and is of good value in the study on high-altitude-related cerebral hemodynamics.