CAJ | 학술논문

目的通过经颅多普勒超声(TCD)动态评价他汀类药物对缺血性卒中脑血流动力学的影响.方法通过TCD检查70例首次急性缺血性卒中住院患者的脑血流动力学,根据他们是否规律服用他汀类药物分为服药组和非服药组.发病3个月后再次随访TCD.结果发现服药组患者发病3个月后双侧大脑中动脉收缩期血流速度、平均血流速度均较发病1周内有上升(P＜0.05).服药组患者发病3个月后双侧大脑中动脉搏动指数较发病1周内有下降(P＜0.05).非服药组患者发病3个月后双侧大脑中动脉血流速度、搏动指数较发病1周内差异无统计学意义(P＞0.05).结论他汀类药物对改善缺血性卒中脑血流动力学有一定的作用.
목적 통과경로다보륵초성(TCD)동태평개타정류약물대결혈성졸중뇌혈류동역학적영향.방법 통과TCD검사70례수차급성결혈성졸중주원환자적뇌혈류동역학,근거타문시부규률복용타정류약물분위복약조화비복약조.발병3개월후재차수방TCD.결과 발현복약조환자발병3개월후쌍측대뇌중동맥수축기혈류속도、평균혈류속도균교발병1주내유상승(P＜0.05).복약조환자발병3개월후쌍측대뇌중동맥박동지수교발병1주내유하강(P＜0.05).비복약조환자발병3개월후쌍측대뇌중동맥혈류속도、박동지수교발병1주내차이무통계학의의(P＞0.05).결론 타정류약물대개선결혈성졸중뇌혈류동역학유일정적작용.
Objective To evaluate the effects of statins on the cerebral haemodynamics of ischemic stroke patients with transcranial Doppler(TCD). Methods 70 inpatients with acute ischemic stroke were divided into two groups according whether they had taken statins after stroke.The change of the cerebral haemodynamics was studied in the two groups with TCD three months after stroke. Results Three months later,the systolic flow velocities and mean flow velocities of bilateral middle cerebral arteries in the statins groups significantly increased (P＜0.05). The pulse index of bilateral middle cerebral arteries in statins group significantly decreased (P＜0.05).The flow velocities and pulse index of bilateral middle cerebral arteries in control group don't change significantly(P＞0.05). Conclusions Statins may have the effects of improving the situation of cerebral haemodynamics of patients with ischemic stroke.