中华普通外科杂志
中華普通外科雜誌
중화보통외과잡지
CHINESE JOURNAL OF GENERAL SURGERY
2012年
7期
560-563
,共4页
庄新荣%刘红%王彤%陆苏
莊新榮%劉紅%王彤%陸囌
장신영%류홍%왕동%륙소
乳腺肿瘤%病理学%临床%分子亚型
乳腺腫瘤%病理學%臨床%分子亞型
유선종류%병이학%림상%분자아형
Breast neoplasms%Pathology%clinical%Molecular subtype
目的 探讨双侧原发性乳腺癌(bilateral primary breast cancer,BPBC)各分子亚型的临床病理特征及第一癌与第二癌分子亚型的一致性.方法 回顾性分析145例BPBC患者的临床病理资料,分析各分子亚型的临床病理特征,第一癌与第二癌间各分子亚型的一致性情况.结果 第一癌Luminal A型91例(62.8％),Luminal B型13例(9.0％),人表皮生长因子受体2(humanepidermal growth factor receptor 2,HER-2)型14例(9.7％),三阴性乳腺癌(triple negative breast cancer,TNBC)27例(18.6％)；第二癌Luminal A型93例(64.1％),Luminal B型10例(6.9％),HER-2型14例(9.7％),TNBC 28例(19.3％).BPBC第一癌中,TNBC≤50岁及组织学Ⅲ级患者明显多于其他亚型(P＜0.05),各分子亚型在肿瘤大小、临床分期、淋巴结转移及病理类型上差异无统计学意义(均P＞0.05).第一癌与第二癌间Lumina A型和TNBC具有较好的一致性(K＞0.40),而Luminal B型和HER-2型的一致性较差(K＜0.40).两癌间隔时间短的BPBC分子亚型一致性较高.结论 BPBC各分子亚型的构成比及临床特征与单侧乳腺癌相似,LuminaA型、TNBC及两癌间隔时间短的BPBC其两侧分子亚型具有较好的一致性.
目的 探討雙側原髮性乳腺癌(bilateral primary breast cancer,BPBC)各分子亞型的臨床病理特徵及第一癌與第二癌分子亞型的一緻性.方法 迴顧性分析145例BPBC患者的臨床病理資料,分析各分子亞型的臨床病理特徵,第一癌與第二癌間各分子亞型的一緻性情況.結果 第一癌Luminal A型91例(62.8％),Luminal B型13例(9.0％),人錶皮生長因子受體2(humanepidermal growth factor receptor 2,HER-2)型14例(9.7％),三陰性乳腺癌(triple negative breast cancer,TNBC)27例(18.6％)；第二癌Luminal A型93例(64.1％),Luminal B型10例(6.9％),HER-2型14例(9.7％),TNBC 28例(19.3％).BPBC第一癌中,TNBC≤50歲及組織學Ⅲ級患者明顯多于其他亞型(P＜0.05),各分子亞型在腫瘤大小、臨床分期、淋巴結轉移及病理類型上差異無統計學意義(均P＞0.05).第一癌與第二癌間Lumina A型和TNBC具有較好的一緻性(K＞0.40),而Luminal B型和HER-2型的一緻性較差(K＜0.40).兩癌間隔時間短的BPBC分子亞型一緻性較高.結論 BPBC各分子亞型的構成比及臨床特徵與單側乳腺癌相似,LuminaA型、TNBC及兩癌間隔時間短的BPBC其兩側分子亞型具有較好的一緻性.
목적 탐토쌍측원발성유선암(bilateral primary breast cancer,BPBC)각분자아형적림상병리특정급제일암여제이암분자아형적일치성.방법 회고성분석145례BPBC환자적림상병리자료,분석각분자아형적림상병리특정,제일암여제이암간각분자아형적일치성정황.결과 제일암Luminal A형91례(62.8％),Luminal B형13례(9.0％),인표피생장인자수체2(humanepidermal growth factor receptor 2,HER-2)형14례(9.7％),삼음성유선암(triple negative breast cancer,TNBC)27례(18.6％)；제이암Luminal A형93례(64.1％),Luminal B형10례(6.9％),HER-2형14례(9.7％),TNBC 28례(19.3％).BPBC제일암중,TNBC≤50세급조직학Ⅲ급환자명현다우기타아형(P＜0.05),각분자아형재종류대소、림상분기、림파결전이급병리류형상차이무통계학의의(균P＞0.05).제일암여제이암간Lumina A형화TNBC구유교호적일치성(K＞0.40),이Luminal B형화HER-2형적일치성교차(K＜0.40).량암간격시간단적BPBC분자아형일치성교고.결론 BPBC각분자아형적구성비급림상특정여단측유선암상사,LuminaA형、TNBC급량암간격시간단적BPBC기량측분자아형구유교호적일치성.
Objective To analyze the clinicopathological features of bilateral primary breast cancer (BPBC) by molecular subtypes.Methods Clinical data of 145 BPBC patients were reviewed focusing on the clinicopathological features of different molecular subtype and the concordance of molecular subtype between first and second primary breast cancers.Results Of the first primary breast cancers ( FPBC),91 cases (62.8％ ) were Luminal A subtype,Luminal B subtype in 13 cases (9.0％ ),Human epidermal growth factor receptor 2 (HER-2) subtype in 14 cases (9.7％ ),triple negative breast cancer (TNBC) in 27 cases ( 18.6％ ).Of the second primary breast cancers ( SPBC ),Luminal A subtype was found in 93 (64.1％ ) cases,Luminal B subtype in 10(6.9％ ) cases,HER-2 subtype in 14(9.7％ ) cases and TNBC in 28( 19.3％ ) cases.Most TNBC patients were young ( age ≤ 50 ) with high frequency of grade Ⅲ in FPBC.Molecular subtypes do not vary with tumor size,clinical stage,lymph node status and pathological types ( P ＞ 0.05 ).Most FPBC of Luminal A and TNBC were concordant same subtypes in SPBC ( K ＞ 0.04 ),while Luminal B and HER-2 subtypes often had discordant phenotypes in SPBC ( K ＜ 0.04).BPBC were more likely to have concordant subtypes if the two tumors developed in short time interval.Conclusions The distribution and clinical leatures of each subtype in BPBC is similar to unilateral breast cancer.Patients whose FPBC are Luminal A or TNBC often have concordant phenotypes for their SPBC,a short time interval between two cancers also predicts concordance.
