CAJ | 학술논문

目的探讨伴随高血压病程延长溶血磷脂酸相似磷脂(AP)水平的变化.方法随机入选原发性高血压患者170例,正常对照79名.将病程长度与AP进行相关分析,并对比其他11项生化指标.结果 AP与高血压病程长度显著正相关,相关系数β=0.186,P=0.015.患者年龄与AP不显著相关,β=0.027 P=0.71.病程≥10年与<10年相比,AP中等以上增高的人数明显增多.x~2值=6.51,P=0.012.优势比OR=2.444,95%CI=1.219～4.903.血脂等11项与病程长度不显著相关.结论与其他11项指标对比,仅AP与高血压病程显著正相关,提示高血压病程延长可能伴随氧化应激损伤的增加.AP在临床上可能有重要的价值.
목적 탐토반수고혈압병정연장용혈린지산상사린지(AP)수평적변화.방법 수궤입선원발성고혈압환자170례,정상대조79명.장병정장도여AP진행상관분석,병대비기타11항생화지표.결과 AP여고혈압병정장도현저정상관,상관계수β=0.186,P=0.015.환자년령여AP불현저상관,β=0.027 P=0.71.병정≥10년여<10년상비,AP중등이상증고적인수명현증다.x~2치=6.51,P=0.012.우세비OR=2.444,95%CI=1.219～4.903.혈지등11항여병정장도불현저상관.결론 여기타11항지표대비,부AP여고혈압병정현저정상관,제시고혈압병정연장가능반수양화응격손상적증가.AP재림상상가능유중요적개치.
Objective To investigate the correlation between length of hypertension history with plasma level of A Phospholipids Component with the Similar Solubility of Lyso-Phosphatidic Acid ( APCSSLPA or briefly AP). So that to farther understand the changes accompanied with prolongation of hypertension history. Methods This is a small cross-sectional study. 170 patients with primary hypertension and 79 normal controls without hypertension history were enrolled. The lengths of case history were recorded and compared with their plasma levels of AP. Similar study were also conducted on other 11 clinical makers as references. Results AP correlated significantly with the length of hypertension history. Correlation coefficient β is 0. 186, P =0.015. But AP did not correlated significantly with systolic or diastolic pressure of patients. The age of patients did not correlated with AP either (β=0. 027, P =0. 71). The patient's number with middle or high level of AP was significantly larger in the group in which hypertension history was 10 years or more, than in the group in which hypertension history was less then 10 years. X~2 =6. 51 ,P =0.012. OR =2.444, 95% CI = 1. 219 -4.903. However, lysophosphatidic acid and other 10 bio-makers which often be used in cerebrovascular and cardiovascular diseases, such as blood lipid, blood sugar, different kinds of lipoprotein and D-dimer etc. did not correlated significantly with hypertension history. Conclusion Comparing with 11 clinical makers, AP was the only one correlated with the length of hypertension history. Our findings suggest: the prolongation of hypertension history may accompanied with increased oxidative damages. The patients with prolonged hypertension history should prevent this possible threaten. Furthermore, AP is a very promising marker with unique worth in cardiovascular and cerebrovascular diseases.