中华预防医学杂志
中華預防醫學雜誌
중화예방의학잡지
CHINESE JOURNAL OF
2012年
6期
538-542
,共5页
刘顺%仇小强%曾小云%柏桦%许杨%张艳艳%潘冬香%毛良勤%黄秋兰
劉順%仇小彊%曾小雲%柏樺%許楊%張豔豔%潘鼕香%毛良勤%黃鞦蘭
류순%구소강%증소운%백화%허양%장염염%반동향%모량근%황추란
癌,肝细胞%多态性,单核苷酸%病例对照研究%性激素结合球蛋白
癌,肝細胞%多態性,單覈苷痠%病例對照研究%性激素結閤毬蛋白
암,간세포%다태성,단핵감산%병례대조연구%성격소결합구단백
Carcinoma,hepatocellular%Polymorphism,single nucleotide%Case-control studies%Sex hormone-binding globulin
目的 探讨性激素结合球蛋白基因Asp327Asn( rs6259)位点单核苷酸多态性与肝细胞肝癌(HCC)发生的关系.方法 以2007年1月至2010年6月广西某两家医院的621例HCC患者为病例组,以同期、同医院621例非肿瘤患者为对照,对Asp327Asn位点进行单核苷酸多态性(SNP)分型,并以多因素非条件logistic回归模型分析不同基因型人群HCC发生风险及基因型与环境因素的交互作用,采用Kaplan-Meier生存分析探讨各基因型与HCC发病年龄的关系.结果 Asp/Asp、Asp/Asn、Asn/Asn基因型在病例组中的频率分别为86.31%( 536/621)、12.40%( 77/621)、1.29%(8/621),在对照组中的分别为81.00% (503/621)、17.39%( 108/621)、1.61%( 10/621),差异有统计学意义(x2=6.465.P<0.05).多因素logistic回归结果表明,与携带基因型Asp/Asp个体相比,携带Asn/Asn或Asp/Asn基因型者发生HCC的风险降低(校正后OR =0.63,95% CI:0.40~0.98).交互作用分析发现,该位点多态性与饮酒(校正后OR=3.45,95% CI:1.74 ~6.83)、乙型肝炎病毒(HBV)感染(校正后OR=40.77,95% CI:21.60 ~76.97)存在交互作用.生存分析显示,具有饮酒史的男性HCC患者中,携带Asp/Asp基因型者的发病年龄为(47.99±0.75)岁,比携带等位基因Asn基因型者[(53.68±2.07)岁]提前约6年(x2=6.91,P<0.01).结论 性激素结合球蛋白基因Asp327Asn位点多态性可能与HCC发生风险和发病年龄有关.
目的 探討性激素結閤毬蛋白基因Asp327Asn( rs6259)位點單覈苷痠多態性與肝細胞肝癌(HCC)髮生的關繫.方法 以2007年1月至2010年6月廣西某兩傢醫院的621例HCC患者為病例組,以同期、同醫院621例非腫瘤患者為對照,對Asp327Asn位點進行單覈苷痠多態性(SNP)分型,併以多因素非條件logistic迴歸模型分析不同基因型人群HCC髮生風險及基因型與環境因素的交互作用,採用Kaplan-Meier生存分析探討各基因型與HCC髮病年齡的關繫.結果 Asp/Asp、Asp/Asn、Asn/Asn基因型在病例組中的頻率分彆為86.31%( 536/621)、12.40%( 77/621)、1.29%(8/621),在對照組中的分彆為81.00% (503/621)、17.39%( 108/621)、1.61%( 10/621),差異有統計學意義(x2=6.465.P<0.05).多因素logistic迴歸結果錶明,與攜帶基因型Asp/Asp箇體相比,攜帶Asn/Asn或Asp/Asn基因型者髮生HCC的風險降低(校正後OR =0.63,95% CI:0.40~0.98).交互作用分析髮現,該位點多態性與飲酒(校正後OR=3.45,95% CI:1.74 ~6.83)、乙型肝炎病毒(HBV)感染(校正後OR=40.77,95% CI:21.60 ~76.97)存在交互作用.生存分析顯示,具有飲酒史的男性HCC患者中,攜帶Asp/Asp基因型者的髮病年齡為(47.99±0.75)歲,比攜帶等位基因Asn基因型者[(53.68±2.07)歲]提前約6年(x2=6.91,P<0.01).結論 性激素結閤毬蛋白基因Asp327Asn位點多態性可能與HCC髮生風險和髮病年齡有關.
목적 탐토성격소결합구단백기인Asp327Asn( rs6259)위점단핵감산다태성여간세포간암(HCC)발생적관계.방법 이2007년1월지2010년6월엄서모량가의원적621례HCC환자위병례조,이동기、동의원621례비종류환자위대조,대Asp327Asn위점진행단핵감산다태성(SNP)분형,병이다인소비조건logistic회귀모형분석불동기인형인군HCC발생풍험급기인형여배경인소적교호작용,채용Kaplan-Meier생존분석탐토각기인형여HCC발병년령적관계.결과 Asp/Asp、Asp/Asn、Asn/Asn기인형재병례조중적빈솔분별위86.31%( 536/621)、12.40%( 77/621)、1.29%(8/621),재대조조중적분별위81.00% (503/621)、17.39%( 108/621)、1.61%( 10/621),차이유통계학의의(x2=6.465.P<0.05).다인소logistic회귀결과표명,여휴대기인형Asp/Asp개체상비,휴대Asn/Asn혹Asp/Asn기인형자발생HCC적풍험강저(교정후OR =0.63,95% CI:0.40~0.98).교호작용분석발현,해위점다태성여음주(교정후OR=3.45,95% CI:1.74 ~6.83)、을형간염병독(HBV)감염(교정후OR=40.77,95% CI:21.60 ~76.97)존재교호작용.생존분석현시,구유음주사적남성HCC환자중,휴대Asp/Asp기인형자적발병년령위(47.99±0.75)세,비휴대등위기인Asn기인형자[(53.68±2.07)세]제전약6년(x2=6.91,P<0.01).결론 성격소결합구단백기인Asp327Asn위점다태성가능여HCC발생풍험화발병년령유관.
Objective This study aims to investigate the correlation between polymorphism of sex hormone-binding globulin (SHBG) Asp327Asn (rs6259) locus and occurence of hepatocellular carcinoma (HCC).Methods 621 cases with HCC and 621 cancer-free controls from two hospitals of Guangxi were recruited from January,2007 to June,2010.Single nucleotide polymorphisms (SNP) of SHBG Asp327Asn were detected by AB17500 Fast Real-Time fluorescence quantitative PCR.Multivariate unconditional logistic regression was applied to analyze risk of HCC among different genotypes carriers and their interaction with the exposure factors.The Kaplan-Meier survival analysis was used to detect the relationship between onset age of HCC and genotypes.Results The frequencies of Asp/Asp,Asp/Asn and Asn/Aan genotype in case group were 86.31% ( 536/621 ),12.40% ( 77/621 ) and 1.29% ( 8/621 ),respectively; while those in control group were 81.00% ( 503/621 ),17.39% ( 108/621 ) and 1.61% ( 10/621 ),respectively,Significant difference in the genotype frequencies distribution was found between case and control groups ( x2 =6.465,P<0.05).Compared with those harboring Asp/Asp genotype,multivariate logistie regression analysis revealed that the HCC risk of Ash/Asn + Asp/Asn genotype carriers was significantly decreased ( adjusted OR =0.63,95% CI:0.40 -0.98 ).Interaction analysis showed that there was interaction between the polymorphisms and two exposure factors,drinking ( adjusted OR =3.45,95% CI:1.74 - 6.83 ) and HBVinfection( adjusted OR =40.77,95% CI:21.60 - 76.97 ).Among those male patients with history of drinking,survival analysis indicated that the mean age of onset of individuals harboring Asp/Asp genotypes ( (47.99 ±0.75 ) years-old) was 6 years earlier than those with Asn/Asn or Asp/Asn genotypes( (53.68 ±2.07) years-old) (x2 =6.91,P<0.01).Conclusion Polymorphism of SHBG(Asp327Asn) may be associated with both the risk of HCC occurence and onset age of HCC.