CAJ | 학술논문

目的:探讨Twist和HIF-1α蛋白在乳腺癌组织中表达及其相关性.方法: 应用免疫组织化学法检测60例乳腺癌组织Twist、HIF-1α蛋白表达情况.结果: 乳腺癌组织中Twist阳性表达为56.7%(34/60),HIF-1α阳性表达为68.3%(41/60),在乳腺癌组织中Twist、HIF-1α蛋白的表达之间存在显著正相关,r=0.518,P<0.01.结论: 乳腺癌组织中存在Twist、HIF-1α蛋白的高表达,且两者间具相关性.HIF-1α蛋白可能通过上调Twist表达,成为其促进乳腺癌浸润、转移的可能途径之一.
목적:탐토Twist화HIF-1α단백재유선암조직중표체급기상관성.방법: 응용면역조직화학법검측60례유선암조직Twist、HIF-1α단백표체정황.결과: 유선암조직중Twist양성표체위56.7%(34/60),HIF-1α양성표체위68.3%(41/60),재유선암조직중Twist、HIF-1α단백적표체지간존재현저정상관,r=0.518,P<0.01.결론: 유선암조직중존재Twist、HIF-1α단백적고표체,차량자간구상관성.HIF-1α단백가능통과상조Twist표체,성위기촉진유선암침윤、전이적가능도경지일.
Objective:To study the expression of Twist and hypoxia inducible factor-1 alpha(HIF-1α) in breast cancer and their realationship. Methods: Expressions of Twist and HIF-1α were detected in 60 cases of breast cancer tissue by immunohistochemistry. Results: The positive Twist expression was 56.7% in breast cancer,and the positive HIF-1α was 68.3%.There was a significant correlation between the expressions of Twist and HIF-1α in breast cancer,r=0.518,P<0.01.Conclusion: The overexpressions of Twist and HIF-1α protein were found in breast cancer.To stimulate Twist may be one of the pathways of HIF-1α protein to contribute to the invasion and metastasis in human breast cancer.