CAJ | 학술논문

[目的]探讨代森锰原药的致突变性.[方法]用KM小鼠进行小鼠骨髓多染红细胞微核试验和小鼠睾丸精母细胞染色体畸变试验,以及鼠伤寒沙门氏菌回复突变(Ames)试验.[结果]在小鼠骨髓多染红细胞微核试验和小鼠睾丸精母细胞染色体畸变试验中,阴性对照组与阳性对照组比较,差异有显著性(P＜0.01);各剂量组与阴性对照组比较,差异均无显著性(P＞0.05),且均低于阳性对照组(P＜0.05,P＜0.01).在Ames试验中,4株试验菌在0.1～1.0 mg/皿的试验剂量下(活化或非活化)均没有引起自发回变数2倍增加.[结论]根据<农药登记毒理学试验方法>中的评定标准,小鼠骨髓多染红细胞微核试验、小鼠睾丸精母细胞染色体畸变试验和鼠伤寒沙门氏菌回复突变试验(Ames试验)在所选剂量范围内结果均为阴性,代森锰原药未呈现致突变性.
[목적]탐토대삼맹원약적치돌변성.[방법]용KM소서진행소서골수다염홍세포미핵시험화소서고환정모세포염색체기변시험,이급서상한사문씨균회복돌변(Ames)시험.[결과]재소서골수다염홍세포미핵시험화소서고환정모세포염색체기변시험중,음성대조조여양성대조조비교,차이유현저성(P＜0.01);각제량조여음성대조조비교,차이균무현저성(P＞0.05),차균저우양성대조조(P＜0.05,P＜0.01).재Ames시험중,4주시험균재0.1～1.0 mg/명적시험제량하(활화혹비활화)균몰유인기자발회변수2배증가.[결론]근거<농약등기독이학시험방법>중적평정표준,소서골수다염홍세포미핵시험、소서고환정모세포염색체기변시험화서상한사문씨균회복돌변시험(Ames시험)재소선제량범위내결과균위음성,대삼맹원약미정현치돌변성.
[Objective]The research aimed to study the mutagenicity of maneb.[Method] KM mice were administered with bone marrow polychromatic erythrocyte micronucleus test and chromosome aberration test, Ames test. [Result] In the test of chromosome aberration and bone marrow polychromatic erythrocyte micronucleus, there was significant difference between the negative group and positive group(P＜0.01), but there was no significant difference between all dose groups and negative group(P＞0.05), and all of them were lower than the positive group (P＜0.05,P＜0.01). Ames test showed that maneb groups didn't cause double increase of revertants. [Conclusion] Maneb has no mutagenic effect.