临床麻醉学杂志
臨床痳醉學雜誌
림상마취학잡지
THE JOURNAL OF CLINICAL ANESTHESIOLOGY
2010年
12期
1037-1039
,共3页
帕瑞昔布钠%镇痛%宫颈癌%吗啡
帕瑞昔佈鈉%鎮痛%宮頸癌%嗎啡
파서석포납%진통%궁경암%마배
Parecoxib sodium%Analgesia%Cervical cancer%Morphine
目的观察帕瑞昔布钠用于腹腔镜宫颈癌根治术超前镇痛效果。方法行腹腔镜宫颈癌根治术患者70例,随机分为两组：帕瑞昔布钠组术前10min给予帕瑞昔布钠40mg,对照组术前给予2ml生理盐水,每隔12小时重复给药。术后均行吗啡PCIA镇痛。采用数字评价量表（NRS）记录拔管即刻、术后2、6、12、18、24h疼痛评分,记录术后24h吗啡总消耗量及不良反应。结果帕瑞昔布钠组各时点NRS疼痛评分显著低于对照组（P〈0.05）,且24h吗啡总消耗量（10.4±7.6）mg,显著少于对照组的（17.7±8.9）mg（P〈0.05）,相应的恶心呕吐及嗜睡发生较对照组为低,24h下床活动人数明显高于对照组（P〈0.05）。结论腹腔镜宫颈癌根治术前应用帕瑞昔布钠40mg可改善单纯吗啡PCIA镇痛效果,减少吗啡用量及不良反应的发生。
目的觀察帕瑞昔佈鈉用于腹腔鏡宮頸癌根治術超前鎮痛效果。方法行腹腔鏡宮頸癌根治術患者70例,隨機分為兩組：帕瑞昔佈鈉組術前10min給予帕瑞昔佈鈉40mg,對照組術前給予2ml生理鹽水,每隔12小時重複給藥。術後均行嗎啡PCIA鎮痛。採用數字評價量錶（NRS）記錄拔管即刻、術後2、6、12、18、24h疼痛評分,記錄術後24h嗎啡總消耗量及不良反應。結果帕瑞昔佈鈉組各時點NRS疼痛評分顯著低于對照組（P〈0.05）,且24h嗎啡總消耗量（10.4±7.6）mg,顯著少于對照組的（17.7±8.9）mg（P〈0.05）,相應的噁心嘔吐及嗜睡髮生較對照組為低,24h下床活動人數明顯高于對照組（P〈0.05）。結論腹腔鏡宮頸癌根治術前應用帕瑞昔佈鈉40mg可改善單純嗎啡PCIA鎮痛效果,減少嗎啡用量及不良反應的髮生。
목적관찰파서석포납용우복강경궁경암근치술초전진통효과。방법행복강경궁경암근치술환자70례,수궤분위량조：파서석포납조술전10min급여파서석포납40mg,대조조술전급여2ml생리염수,매격12소시중복급약。술후균행마배PCIA진통。채용수자평개량표（NRS）기록발관즉각、술후2、6、12、18、24h동통평분,기록술후24h마배총소모량급불량반응。결과파서석포납조각시점NRS동통평분현저저우대조조（P〈0.05）,차24h마배총소모량（10.4±7.6）mg,현저소우대조조적（17.7±8.9）mg（P〈0.05）,상응적악심구토급기수발생교대조조위저,24h하상활동인수명현고우대조조（P〈0.05）。결론복강경궁경암근치술전응용파서석포납40mg가개선단순마배PCIA진통효과,감소마배용량급불량반응적발생。
Objective To observe the preemptive analgesia effect of parecoxib sodium in patients undergoing laparoscopic cervical carcinoma radical resection.Methods Seventy patients undergoing laparoscopic cervical carcinoma radical resection were randomly divided into 2 groups with 35 cases each. Parecoxib sodium 40 mg was injected intravenously 10 min before operation and repeatedly given every 12 h. Equal volume physiological saline was given at same time in the control group. Two groups received postoperative PCIA with morphine. The numerical rating scale （NRS） was used to rate pain intensity at following time points：immediately after extubation,2,6,12,18,and 24 h after operation. Twenty-four hour morphine consumption and side effects were recorded.Results The NRS rating of pain at each time point in the parecoxib group was significantly lower than that of the control group （P0.05）,and the total morphine consumption （10.4±7.6）mg was less than the control （17.7±8.9）mg （P0.05）; correspondingly,the incidences of nausea,vomiting and drowsiness were less,and the number of patients left bed for activity was increased in the parecoxib group than those in the control one （P0.05）. Conclusion Preoperative parecoxib sodium 40 mg can improve the analgesic effect of PCIA with morphine,and reduce morphine consumption and the incidences of side effects.
