中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2008年
4期
623-625
,共3页
葡萄球菌,金黄色%凝固酶%甲氧西林抗药性
葡萄毬菌,金黃色%凝固酶%甲氧西林抗藥性
포도구균,금황색%응고매%갑양서림항약성
Staphylococcus aureus%Coagulase%Meticillin resistance
目的 分析临床分离的耐甲氧西林葡萄球菌(MRS)的分布和耐药性,并探讨对耐药菌感染的治疗策略.方法 对临床分离的568株葡萄球菌,药敏试验及耐甲氧西林葡萄球菌的检测均采用Kirby-Bauer琼脂扩散法,操作及结果判断均按美国国家临床实验室标准委员会(NCCLS)颁布的规则(2000年版)标准执行.结果 筛选出金黄色葡萄球菌(SAO)171株,检出率30.1%,凝固酶阴性葡萄球菌(CNS)397株,检出率为69.8%.其中耐甲氧西林金黄色葡萄球菌(MRSA)36.2%,耐甲氧西林凝固酶阴性葡萄球菌(MRSCON)77.5%,MRSA株对喹诺酮类耐药性(21%～48%)明显低于MRSCDN株(84%～89%).MRS除对万古霉素、利复平、呋喃妥因、阿米卡星和少数青霉素类耐药外,MRSA和MRSCON株的耐药性显著高于甲氧西林敏感葡萄球菌(MSSA)和甲氧西林敏感血浆凝固酶阴性葡萄球菌(MSSCON)株(P＜0.05),未发现VRS株.结论 由MRS菌株引起重症感染应首选糖肽类抗生素万古霉素治疗,葡萄球菌是造成医院感染的主要病原菌之一,MRS具有多重耐药性,应长期进行耐药性检测,提高对抗生素耐药性认识.
目的 分析臨床分離的耐甲氧西林葡萄毬菌(MRS)的分佈和耐藥性,併探討對耐藥菌感染的治療策略.方法 對臨床分離的568株葡萄毬菌,藥敏試驗及耐甲氧西林葡萄毬菌的檢測均採用Kirby-Bauer瓊脂擴散法,操作及結果判斷均按美國國傢臨床實驗室標準委員會(NCCLS)頒佈的規則(2000年版)標準執行.結果 篩選齣金黃色葡萄毬菌(SAO)171株,檢齣率30.1%,凝固酶陰性葡萄毬菌(CNS)397株,檢齣率為69.8%.其中耐甲氧西林金黃色葡萄毬菌(MRSA)36.2%,耐甲氧西林凝固酶陰性葡萄毬菌(MRSCON)77.5%,MRSA株對喹諾酮類耐藥性(21%～48%)明顯低于MRSCDN株(84%～89%).MRS除對萬古黴素、利複平、呋喃妥因、阿米卡星和少數青黴素類耐藥外,MRSA和MRSCON株的耐藥性顯著高于甲氧西林敏感葡萄毬菌(MSSA)和甲氧西林敏感血漿凝固酶陰性葡萄毬菌(MSSCON)株(P＜0.05),未髮現VRS株.結論 由MRS菌株引起重癥感染應首選糖肽類抗生素萬古黴素治療,葡萄毬菌是造成醫院感染的主要病原菌之一,MRS具有多重耐藥性,應長期進行耐藥性檢測,提高對抗生素耐藥性認識.
목적 분석림상분리적내갑양서림포도구균(MRS)적분포화내약성,병탐토대내약균감염적치료책략.방법 대림상분리적568주포도구균,약민시험급내갑양서림포도구균적검측균채용Kirby-Bauer경지확산법,조작급결과판단균안미국국가림상실험실표준위원회(NCCLS)반포적규칙(2000년판)표준집행.결과 사선출금황색포도구균(SAO)171주,검출솔30.1%,응고매음성포도구균(CNS)397주,검출솔위69.8%.기중내갑양서림금황색포도구균(MRSA)36.2%,내갑양서림응고매음성포도구균(MRSCON)77.5%,MRSA주대규낙동류내약성(21%～48%)명현저우MRSCDN주(84%～89%).MRS제대만고매소、리복평、부남타인、아미잡성화소수청매소류내약외,MRSA화MRSCON주적내약성현저고우갑양서림민감포도구균(MSSA)화갑양서림민감혈장응고매음성포도구균(MSSCON)주(P＜0.05),미발현VRS주.결론 유MRS균주인기중증감염응수선당태류항생소만고매소치료,포도구균시조성의원감염적주요병원균지일,MRS구유다중내약성,응장기진행내약성검측,제고대항생소내약성인식.
Objective To analyze distribution and drug resistance of MRSA separated,to probe into a treat method for MRSA infection and offer scientific gist for reasonable use of clinical antibiotic. Methods 568 MRSA separated from clinic were measured and a drug sensitivity test was performed by means of Kirby-Bautr agar diffusion method. Results 370 individual plants were filtered, the rate of inspection was 65.1%. MRSA was 36.2 % among them,MRSCON was 77.5% ,the drug resistance of MRSA to quinolones(21% ～48% ) was below MRSCON(84 %～89 % ). The drug resistance of MRSA and MRSCON obviously excelled MSSA and MSSCON ( P＜0.05 ). VRS was undiscovered. Conclusion Severe infection caused by MRS should choose vancomycin resistant enterococci to cure at fist. Staphylococcus was one of primary pathogenic bacterium caused infection in hospital, MRS had multiple drug resistance and measure range about drug resistance should be extended, which would advance the cognition about the drug resistance of antibiotic and cut off the transmitted path, reduce the drug resistance of bacteria and the infection rate in hospital.
