CAJ | 학술논문

目的建立急性梗阻性脑积水动物实验模型,提高对急性梗阻性脑积水诱发的颅高压的病理生理学认识,探讨其快速有效的治疗措施.方法取成年健康杂种犬9只,经后颅窝手术向第四脑室注入氰基丙烯酸凝胶,诱导建立犬急性梗阻性脑积水模型；同时行侧脑室置管并连接固定于头皮下储液囊,动态测量实验犬的颅内压,并观察其神经功能的变化.结果 6只犬形成急性梗阻性脑积水.诱导后48 h颅内压为(48.2 ±6.1)cm H2O,较诱导前的基础颅内压(12.3 ±3.1)cm H2O增高392％；72 h颅内压为(56.4 ±5.7)cm H2O,较诱导前增高459％,与诱导前颅内压相比差异有统计学意义(t=4.9867和5.6882,P均＜0.01).结论该模型的建立成功率高、简便易行、可重复.既可动态观察颅内压变化,也可快速放出脑脊液,有效降低颅内压.脑室外引流是急性梗阻性脑积水最有效的治疗方法.
목적 건립급성경조성뇌적수동물실험모형,제고대급성경조성뇌적수유발적로고압적병리생이학인식,탐토기쾌속유효적치료조시.방법 취성년건강잡충견9지,경후로와수술향제사뇌실주입청기병희산응효,유도건립견급성경조성뇌적수모형；동시행측뇌실치관병련접고정우두피하저액낭,동태측량실험견적로내압,병관찰기신경공능적변화.결과 6지견형성급성경조성뇌적수.유도후48 h로내압위(48.2 ±6.1)cm H2O,교유도전적기출로내압(12.3 ±3.1)cm H2O증고392％；72 h로내압위(56.4 ±5.7)cm H2O,교유도전증고459％,여유도전로내압상비차이유통계학의의(t=4.9867화5.6882,P균＜0.01).결론 해모형적건립성공솔고、간편역행、가중복.기가동태관찰로내압변화,야가쾌속방출뇌척액,유효강저로내압.뇌실외인류시급성경조성뇌적수최유효적치료방법.
Objective To gain more pathophysiolgic knowledge about acute obstructive hydrocephalus and to explore its rapid and effective treatment by establishing canine acute obstructive hydrocephalus model.Methods Acute obstructive hydrocephalus model was established by injecting cyan-acrylic gel glue into the fourth ventricle via posterior fosse craniotomy in 9 male adult mongrel dogs.At the same time,lateral ventricle catheterization were performed and were fixed on the scalp to connect reservoir bag so that the changes of intracranial pressure (ICP) could be measured dynamically,and the changes of neurological function were observed.Results Acute obstructive hydrocephalus model was successfully established in 6 of the total 9dogs.ICP was (48.2 ± 6.1 ) cm H2 O at 48 hours after the injection and was (56.4 ± 5.7 ) cm H2 O at 72 hours after the injection,it increased 392％ and 459 ％ respectively.And the ICP after injection was significantly different(P ＜ 0.01 )compared with that before injection (12.3 ± 3.1 )cm H2O.Conclusion The establishment of acute obstructive hydrocephalus model has high success rate,and is easy to reduplicate; ICP could be measured dynamically and also could be reduced by releasing CSF;Thus,ventricular drainage is the most rapid and effective treatment for acute obstructive hydrocephalus.