CAJ | 학술논문

目的探讨泮托拉唑、克拉霉素及铝碳酸镁三联疗法治疗消化性溃疡的临床疗效及不良反应.方法选择2009年1月-2010年12月126例十二指肠球部溃疡合并幽门螺杆菌(HP)感染患者,并随机分为观察组和对照组各63例,观察组给予泮托拉唑、克拉霉素及铝碳酸镁三联疗法治疗7 d后,继续单服用泮托拉唑3周.对照组给予奥美拉唑、克拉霉素及阿莫西林三联治疗7 d后,继续单服用奥美拉唑3周.两组治疗4周后复查胃镜并检测HP,评价其疗效.结果观察组与对照组溃疡愈合率分别为93.65%、90.48%,根除率分别为95.24%、88.89%,两组间均差异无显著性(P＞0.05),不良反应对照组明显大于观察组(P＜0.05).结论泮托拉唑三联疗法是一种根除率较高,不良反应少并且安全可靠的治疗消化性溃疡和HP根除的理想方法.
목적 탐토반탁랍서、극랍매소급려탄산미삼련요법치료소화성궤양적림상료효급불량반응.방법 선택2009년1월-2010년12월126례십이지장구부궤양합병유문라간균(HP)감염환자,병수궤분위관찰조화대조조각63례,관찰조급여반탁랍서、극랍매소급려탄산미삼련요법치료7 d후,계속단복용반탁랍서3주.대조조급여오미랍서、극랍매소급아막서림삼련치료7 d후,계속단복용오미랍서3주.량조치료4주후복사위경병검측HP,평개기료효.결과 관찰조여대조조궤양유합솔분별위93.65%、90.48%,근제솔분별위95.24%、88.89%,량조간균차이무현저성(P＞0.05),불량반응대조조명현대우관찰조(P＜0.05).결론 반탁랍서삼련요법시일충근제솔교고,불량반응소병차안전가고적치료소화성궤양화HP근제적이상방법.
Objective To explore the efficacy of triple therapy with pantoprazole, clarithromycin, and hydrotalcite for peptic ulcer and the therapy-related adverse reactions. Methods 126 patients with duodenal ulcer due to H. pylori infection were randomly assigned to receive triple therapy with pantoprazole, clarithromycin, and hydrotalcite for seven days and then pantoprazole alone for three weeks(study group, 63 patients), or triple therapy with omeprazole, clarithromycin, and amoxicillin for seven days and then omeprazole alone for three weeks(control group, 63 patients). Four weeks after treatment, gastroscopy and H. pylori detection were performed to assess the efficacy in both groups. Results The ulcer healing rate and eradication rate did not differ significantly between the study group and the control group(93.65% vs. 90.48% and 95.24% vs. 88.89%, P ＞ 0.05). The incidence rate of adverse reactions was higher in the control group than in the study group(P ＜ 0.05). Conclusions Pantoprazolebased triple therapy is a safe, reliable protocol for peptic ulcer and H. pylori eradication, and has a higher eradication rate and fewer adverse reactions.