中华急诊医学杂志
中華急診醫學雜誌
중화급진의학잡지
CHINESE JOURNAL OF EMERGENCY MEDICINE
2010年
12期
1317-1319
,共3页
蔡晨%徐庆连%胡宏%唐益忠%戚伟伟
蔡晨%徐慶連%鬍宏%唐益忠%慼偉偉
채신%서경련%호굉%당익충%척위위
血必净%烧伤%二胺氧化酶%内毒素%肿瘤坏死因子-α%白细胞介素-6
血必淨%燒傷%二胺氧化酶%內毒素%腫瘤壞死因子-α%白細胞介素-6
혈필정%소상%이알양화매%내독소%종류배사인자-α%백세포개소-6
Xuebijing%Burns%Diamine oxidase%Lipopolysaccharide%Tumor necrosis factor-α%Interleukin-6
目的 探讨血必净注射液对严重烧伤患者肠道功能及炎症反应的影响.方法 将同期严重程度相当的32例严重烧伤患者随机(随机数字法)分为血必净治疗组(n=16)和对照组(n=16).对照组按烧伤常规治疗;治疗组在常规治疗基础上给予血必净注射液,每次100 mL,静脉滴注,2次/d,连续使用7 d.检测两组患者治疗前与治疗后3 d和7 d血浆二胺氧化酶(DAO)、内毒素(LPS)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平变化.采用SPSS 12.0统计软件进行统计分析.结果 两组烧伤患者治疗后,血浆DAO,LPS,TNF-α及IL-6水平均较治疗前下降(P＜0.05);血必净治疗组在治疗后3 d和7 d,血浆DAO,LPS,TNF-α及IL-6水平明显低于对照组(P＜0.05).结论 血必净注射液可保护烧伤患者肠道功能,减少内毒素人血,对改善严重烧伤患者的炎症反应有积极作用.
目的 探討血必淨註射液對嚴重燒傷患者腸道功能及炎癥反應的影響.方法 將同期嚴重程度相噹的32例嚴重燒傷患者隨機(隨機數字法)分為血必淨治療組(n=16)和對照組(n=16).對照組按燒傷常規治療;治療組在常規治療基礎上給予血必淨註射液,每次100 mL,靜脈滴註,2次/d,連續使用7 d.檢測兩組患者治療前與治療後3 d和7 d血漿二胺氧化酶(DAO)、內毒素(LPS)、腫瘤壞死因子-α(TNF-α)、白細胞介素-6(IL-6)水平變化.採用SPSS 12.0統計軟件進行統計分析.結果 兩組燒傷患者治療後,血漿DAO,LPS,TNF-α及IL-6水平均較治療前下降(P＜0.05);血必淨治療組在治療後3 d和7 d,血漿DAO,LPS,TNF-α及IL-6水平明顯低于對照組(P＜0.05).結論 血必淨註射液可保護燒傷患者腸道功能,減少內毒素人血,對改善嚴重燒傷患者的炎癥反應有積極作用.
목적 탐토혈필정주사액대엄중소상환자장도공능급염증반응적영향.방법 장동기엄중정도상당적32례엄중소상환자수궤(수궤수자법)분위혈필정치료조(n=16)화대조조(n=16).대조조안소상상규치료;치료조재상규치료기출상급여혈필정주사액,매차100 mL,정맥적주,2차/d,련속사용7 d.검측량조환자치료전여치료후3 d화7 d혈장이알양화매(DAO)、내독소(LPS)、종류배사인자-α(TNF-α)、백세포개소-6(IL-6)수평변화.채용SPSS 12.0통계연건진행통계분석.결과 량조소상환자치료후,혈장DAO,LPS,TNF-α급IL-6수평균교치료전하강(P＜0.05);혈필정치료조재치료후3 d화7 d,혈장DAO,LPS,TNF-α급IL-6수평명현저우대조조(P＜0.05).결론 혈필정주사액가보호소상환자장도공능,감소내독소인혈,대개선엄중소상환자적염증반응유적겁작용.
Objective To investigate the effects of Xuebijing injectio (Chinese herb preparation) on intestinal function and inflammatory responses in severe burn patients. Method Thirty-two patients with comparable severity in burn injury were randomly divided into Xuebijing injectio treatment group (n = 16) and control group (n = 16). Patients in both groups received routine burn therapy, while those in Xuebijing treatment group additionally received Xuebijing injectio 100mL in intravenous drip twice a day for 7 days. Before the treatment and on the 3rd and the 7th day after the treatment, blood concentrations of diamine oxidase (DAO), lipopolysaccharide (LPS) ,tumor necrosis factor-α(TNF-α) and interleukin-6 (IL-6) were determined in both groups. Analysis was made by SPSS 12.0 software. Results The plasma levels of DAO, LPS, TNF-α and IL-6 were decreased in both groups after the treatment. However, the plasma levels of DAO, LPS, TNF-α and IL-6 in the Xuebijing treatment group were significantly lower than those in control group on the 3rd and 7th day after the treatment (P＜ 0.05).Conclusions Xuebijing injectio could protect intestinal function, decrease the plasma level of endotoxin and lessen zhe inflammatory responses in severe burn patients.
