CAJ | 학술논문

目的研究活体亲属肾移植供受者HLA配合率,为临床选择良好的供受者HLA配型提供参考.方法对2006年4月-2008年12月间手术的222例活体亲属肾移植患者进行HLA供受者配合率分析.移植受者男性168例,女性54例,最大年龄58,最小年龄10岁;移植供者男性133例,女性89例,最大年龄64岁,最小年龄21岁.结果 87例接受父母移植肾患者HLA-A、B、DR、DQ抗原半相合,其中有14例抗原配合率高于半相合.7例接受子女移植肾患者HLA-A、B、DR、DQ抗原半相合,其中有2例HLA抗原配合率高于半相合.56例接受兄弟姐妹间移植肾患者HLA-A、B、DR、DQ配型完全相配合有12例,34例为半相合,其余为低于半相合或不相合.72例接受其他活体移植的供受者间HLA-A、B、DR、DQ大于半相合的有20例;完全不相合的有5例;虽然HLA抗原配合率大于4个抗原,但并不是半相合抗原的有6例;等于或小于3个抗原配合的有41例.结论父母、子女及兄弟姊妹间的直系亲属肾移植供受者中HLA配合率高于其他亲属间移植供受者.
목적 연구활체친속신이식공수자HLA배합솔,위림상선택량호적공수자HLA배형제공삼고.방법 대2006년4월-2008년12월간수술적222례활체친속신이식환자진행HLA공수자배합솔분석.이식수자남성168례,녀성54례,최대년령58,최소년령10세;이식공자남성133례,녀성89례,최대년령64세,최소년령21세.결과 87례접수부모이식신환자HLA-A、B、DR、DQ항원반상합,기중유14례항원배합솔고우반상합.7례접수자녀이식신환자HLA-A、B、DR、DQ항원반상합,기중유2례HLA항원배합솔고우반상합.56례접수형제저매간이식신환자HLA-A、B、DR、DQ배형완전상배합유12례,34례위반상합,기여위저우반상합혹불상합.72례접수기타활체이식적공수자간HLA-A、B、DR、DQ대우반상합적유20례;완전불상합적유5례;수연HLA항원배합솔대우4개항원,단병불시반상합항원적유6례;등우혹소우3개항원배합적유41례.결론 부모、자녀급형제자매간적직계친속신이식공수자중HLA배합솔고우기타친속간이식공수자.
Objective To study the HLA match rate of 222 living-related donors for kidney transplantation, and to give suggestions for clinical selection of suitable donors and recipients. Methods We analyzed the HLA match rate of 222 kidney transplantations from living relative donors from April 2006 to December 2008. There were 168 male recipients and 54 female recipients. The ages of 222 recipients ranged from 10 to 58. There were 133 male donors and 89 female donors. The ages of 222 recipients ranged from 21 to 64.Results The HLA-A, B, DR, DR, antigens of 87 kidney transplantations from living parental donors were half-matched, of which 14 were higher than half-matched. The HLA-A, B, DR, DQ antigens of 7 kidney transplantations from living children donors were half-matched, including 2 cases higher than half-matched.Among 56 kidney transplantations from living sibling donors, 12 cases were totally mated, 34 cases were half-matched, and the rest were less than half-matched or mismatched. Among 72 kidney transplantations from other living relative donors, 20 cases were higher than half-matched and 5 cases were completely mismatched. More than 4 HLA antigens in 6 cases were matched, but not half-matched. Three HLA antigens or less were matched in 41 cases. Conclusion The HLA match rates from living parental, children, or sibling donors were higher than other relative donors.