国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2012年
7期
497-500
,共4页
唐文辉%周南南%钟小燕%孙延生%王冬梅%刘灼帆%宛太
唐文輝%週南南%鐘小燕%孫延生%王鼕梅%劉灼帆%宛太
당문휘%주남남%종소연%손연생%왕동매%류작범%완태
慢性阻塞性肺疾病%肿瘤坏死因子α%青兰浸膏片
慢性阻塞性肺疾病%腫瘤壞死因子α%青蘭浸膏片
만성조새성폐질병%종류배사인자α%청란침고편
Chronic obstructive pulmonary disease%Tumor necrosis factor-α%Qinglan jingao tabales
目的 探索青兰浸膏片对慢性阻塞性肺疾病(COPD)的防治作用及可能的抗炎机制.方法 本研究以青兰浸膏片治疗慢性阻塞性肺疾病急性加重期(AECOPD)患者为研究对象,采用酶联免疫吸附法测定患者治疗前后血清肿瘤坏死因子α(TNF-α)、白介素8(IL-8)水平,同时进行肺功能测定,比较观察青兰浸膏片治疗前后患者血清TNF-α、IL-8及肺功能的变化,并对其变化进行相关性研究.结果 青兰浸膏片治疗AECOPD患者后血清TNF-α、IL-8水平明显下降( P＜0.01),英国医学研究会(MRC)呼吸困难评分明显降低(P＜0.01),肺功能FEV1％pred、FEV、/FVC、MVV、PEF有明显改善(P＜0.01).结论 青兰浸膏片治疗能明显下降AECOPD患者血清TNF-α和IL-8水平,明显改善呼吸困难程度及肺的通气功能.
目的 探索青蘭浸膏片對慢性阻塞性肺疾病(COPD)的防治作用及可能的抗炎機製.方法 本研究以青蘭浸膏片治療慢性阻塞性肺疾病急性加重期(AECOPD)患者為研究對象,採用酶聯免疫吸附法測定患者治療前後血清腫瘤壞死因子α(TNF-α)、白介素8(IL-8)水平,同時進行肺功能測定,比較觀察青蘭浸膏片治療前後患者血清TNF-α、IL-8及肺功能的變化,併對其變化進行相關性研究.結果 青蘭浸膏片治療AECOPD患者後血清TNF-α、IL-8水平明顯下降( P＜0.01),英國醫學研究會(MRC)呼吸睏難評分明顯降低(P＜0.01),肺功能FEV1％pred、FEV、/FVC、MVV、PEF有明顯改善(P＜0.01).結論 青蘭浸膏片治療能明顯下降AECOPD患者血清TNF-α和IL-8水平,明顯改善呼吸睏難程度及肺的通氣功能.
목적 탐색청란침고편대만성조새성폐질병(COPD)적방치작용급가능적항염궤제.방법 본연구이청란침고편치료만성조새성폐질병급성가중기(AECOPD)환자위연구대상,채용매련면역흡부법측정환자치료전후혈청종류배사인자α(TNF-α)、백개소8(IL-8)수평,동시진행폐공능측정,비교관찰청란침고편치료전후환자혈청TNF-α、IL-8급폐공능적변화,병대기변화진행상관성연구.결과 청란침고편치료AECOPD환자후혈청TNF-α、IL-8수평명현하강( P＜0.01),영국의학연구회(MRC)호흡곤난평분명현강저(P＜0.01),폐공능FEV1％pred、FEV、/FVC、MVV、PEF유명현개선(P＜0.01).결론 청란침고편치료능명현하강AECOPD환자혈청TNF-α화IL-8수평,명현개선호흡곤난정도급폐적통기공능.
Objective To explore possible preventive effect and anti-inflammatory mechanism of qinglan jingao tabales in the treatment of chronic obstructive pulmonary disease (COPD).Methods In this study,patients with acute exacerbation stage of chronic obstructive pulmonary disease (AECOPD) by qinglan jingao tabales treatment were treated as the object of study.The serum levels of TNF-α and IL-8 before and after treatment were measured by ELISA method.Meanwhile lung function measurement.To observe the changes of serum TNF-α,IL-8 and pulmonary function in patients with COPD before and after qinglan jingao tabales treatment by comparison,and to study the relationship between them.Results Patients witb AECOPD have been treated by qinglan jingao tabales,the concentration TNF-α,IL-8levels decreased significantly( P ＜0.01),MRC dyspnea score was significantly lower( P ＜0.01 ),lung function FEV1 ％ pred,FEV1 FVC,MV V.PEF improved significantly ( P ＜0.01 ).Conclusions Qinglan jingao tabales treatment significantly decreased AECOPD serum TNF-α and IL-8 levels,significantly improved dyspnea and pulmonary ventilation tunction.
