CAJ | 학술논문

环境内分泌干扰物是普遍存在于环境中的一类外源性化学物质,这些物质可干扰体内天然激素的合成、释放、转运、与受体结合、代谢及清除等各个方面,干扰正常激素维持体内平衡和调节发育过程的作用.环境内分泌干扰物被证实是引起儿童性分化、性发育异常的重要致病因素.环境内分泌干扰物可扰乱下丘脑-垂体-性腺轴,干扰雄激素的生物合成、转运、与受体结合、代谢和清除以及通过环境-基因的交互作用来影响儿童的性分化、性发育进程.
배경내분비간우물시보편존재우배경중적일류외원성화학물질,저사물질가간우체내천연격소적합성、석방、전운、여수체결합、대사급청제등각개방면,간우정상격소유지체내평형화조절발육과정적작용.배경내분비간우물피증실시인기인동성분화、성발육이상적중요치병인소.배경내분비간우물가우란하구뇌-수체-성선축,간우웅격소적생물합성、전운、여수체결합、대사화청제이급통과배경-기인적교호작용래영향인동적성분화、성발육진정.
Environmental endocrine disruptors are pollutants of many exogenous chemical classes,which are ubiquitous and persistent in the environment and can interfere with the body 's natural steroidogenesis,secretion,transport,and receptor binding,biotransformation and removal of other aspects,thus,they may disturb normal hormone maintaining the organism 's balance and regulating development process.Therefore,exposure to these pollutants is one of the biggest factors that induce sex differentiation and sexual abnormality in children,which has been proved by many data from epidemiological researches.Environmental endocrine disruptors may influence the sexual differentiation and sexual development process of children by disturbing the hypothalamus-pituitary-gonadal axis and affecting the biosynthesis,transport,receptor binding,metabolism and clearance of androgen as well as interacting with genes.