CAJ | 학술논문

1型糖尿病是由T细胞介导的自身免疫性疾病.许多研究表明,抗原特异性的CD4~+和CD8~+T细胞在1型糖尿病的发病过程中起重要作用.胰岛细胞特异性葡萄糖-6-磷酸酶催化亚基相关蛋白(IGRP)作为1型糖尿病的主要自身抗原之一,是葡萄糖-6-磷酸酶蛋白家族中的一员,在人和非肥胖糖尿病鼠胰腺中均有表达.它在胰岛β细胞的代谢过程中起重要作用,但是确切机制仍不清楚.IGRP的研究将有助于探索1型糖尿病诊断和治疗的新方法.
1형당뇨병시유T세포개도적자신면역성질병.허다연구표명,항원특이성적CD4~+화CD8~+T세포재1형당뇨병적발병과정중기중요작용.이도세포특이성포도당-6-린산매최화아기상관단백(IGRP)작위1형당뇨병적주요자신항원지일,시포도당-6-린산매단백가족중적일원,재인화비비반당뇨병서이선중균유표체.타재이도β세포적대사과정중기중요작용,단시학절궤제잉불청초.IGRP적연구장유조우탐색1형당뇨병진단화치료적신방법.
Type 1 diabetes is a T cell-mediated autoimmune disease. Many studies have suggested that both CD4~+ and CD8~+ T cells are involved in the pathogenesis of type 1 diabetes. Islet-specific glucose-6-phosphatase catalytic subunit related peptide (IGRP) ,which is recognized as a major autoantigen for autoim-mune type 1 diabetes, is a member of the glucose-6-phosphatsse family. IGRP is expressed in the pancreas of both human and NOD mice and is thought to have a role in islet β cell metabolism. However,its exact func-tion has not yet been defined. The research of IGRP will help to explore new methods of the diagnosis and treatment of type 1 diabetes.