中华肿瘤杂志
中華腫瘤雜誌
중화종류잡지
CHINESE JOURNAL OF ONCOLOGY
2010年
9期
671-675
,共5页
吴文新%段银燕%吕贵华%史淑芬%张杰英%王恒树%张祥宏
吳文新%段銀燕%呂貴華%史淑芬%張傑英%王恆樹%張祥宏
오문신%단은연%려귀화%사숙분%장걸영%왕항수%장상굉
大肠管状腺瘤%JNK1%Raf-1%Livin%免疫组化%癌变
大腸管狀腺瘤%JNK1%Raf-1%Livin%免疫組化%癌變
대장관상선류%JNK1%Raf-1%Livin%면역조화%암변
Colorectal tubular adenoma%JNK1%Raf-1 Livin%Immunohistochemistry%Carcinogenesis
目的 探讨JNK1、Raf-1和Livin在散发性大肠管状腺瘤癌变过程中的可能作用.方法 采用免疫组化方法,检测21例正常大肠黏膜、65例散发性大肠管状腺瘤伴上皮不同程度异型增生及22例管状腺瘤癌变组织中,JNK1 、Raf-1和Livin的蛋白表达水平.结果 正常大肠黏膜组、散发性大肠管状腺瘤伴上皮异型增生组、大肠管状腺瘤癌变组,JNK1蛋白的阳性表达率分别为33.3%、63.1%和90.9%,Raf-1蛋白的阳性表达率分别为23.8%、52.3%和77.3%,Livin蛋白的阳性表达率分别为14.3%、52.3%和77.3%,大肠管状腺瘤伴上皮异型增生组和癌变组JNK1 Raf-1和Livin蛋白的阳性表达率均高于正常大肠黏膜组(均P＜0.05),而癌变组均高于大肠管状腺瘤伴上皮异型增生组(均P＜0.05).在大肠管状腺瘤伴上皮异型增生组中,Raf-1的阳性表达率随异型增生程度的增高而升高(P＜0.05),而上皮不同程度异型增生组间JNK1和Livin蛋白的阳性表达率差异无统计学意义(均P＞0.05).87例散发性大肠管状腺瘤组织中,JNK1、Raf-1和Livin蛋白表达两两正相关(JNK1和Raf-1:r=0.451,P＜0.05;JNK1和Livin:r于0.499,P＜0.05;Raf和Livin;r=0.445,P＜0.05).结论 JNK1、Raf-1和Livin在大肠管状腺瘤癌变过程中可能起一定作用.
目的 探討JNK1、Raf-1和Livin在散髮性大腸管狀腺瘤癌變過程中的可能作用.方法 採用免疫組化方法,檢測21例正常大腸黏膜、65例散髮性大腸管狀腺瘤伴上皮不同程度異型增生及22例管狀腺瘤癌變組織中,JNK1 、Raf-1和Livin的蛋白錶達水平.結果 正常大腸黏膜組、散髮性大腸管狀腺瘤伴上皮異型增生組、大腸管狀腺瘤癌變組,JNK1蛋白的暘性錶達率分彆為33.3%、63.1%和90.9%,Raf-1蛋白的暘性錶達率分彆為23.8%、52.3%和77.3%,Livin蛋白的暘性錶達率分彆為14.3%、52.3%和77.3%,大腸管狀腺瘤伴上皮異型增生組和癌變組JNK1 Raf-1和Livin蛋白的暘性錶達率均高于正常大腸黏膜組(均P＜0.05),而癌變組均高于大腸管狀腺瘤伴上皮異型增生組(均P＜0.05).在大腸管狀腺瘤伴上皮異型增生組中,Raf-1的暘性錶達率隨異型增生程度的增高而升高(P＜0.05),而上皮不同程度異型增生組間JNK1和Livin蛋白的暘性錶達率差異無統計學意義(均P＞0.05).87例散髮性大腸管狀腺瘤組織中,JNK1、Raf-1和Livin蛋白錶達兩兩正相關(JNK1和Raf-1:r=0.451,P＜0.05;JNK1和Livin:r于0.499,P＜0.05;Raf和Livin;r=0.445,P＜0.05).結論 JNK1、Raf-1和Livin在大腸管狀腺瘤癌變過程中可能起一定作用.
목적 탐토JNK1、Raf-1화Livin재산발성대장관상선류암변과정중적가능작용.방법 채용면역조화방법,검측21례정상대장점막、65례산발성대장관상선류반상피불동정도이형증생급22례관상선류암변조직중,JNK1 、Raf-1화Livin적단백표체수평.결과 정상대장점막조、산발성대장관상선류반상피이형증생조、대장관상선류암변조,JNK1단백적양성표체솔분별위33.3%、63.1%화90.9%,Raf-1단백적양성표체솔분별위23.8%、52.3%화77.3%,Livin단백적양성표체솔분별위14.3%、52.3%화77.3%,대장관상선류반상피이형증생조화암변조JNK1 Raf-1화Livin단백적양성표체솔균고우정상대장점막조(균P＜0.05),이암변조균고우대장관상선류반상피이형증생조(균P＜0.05).재대장관상선류반상피이형증생조중,Raf-1적양성표체솔수이형증생정도적증고이승고(P＜0.05),이상피불동정도이형증생조간JNK1화Livin단백적양성표체솔차이무통계학의의(균P＞0.05).87례산발성대장관상선류조직중,JNK1、Raf-1화Livin단백표체량량정상관(JNK1화Raf-1:r=0.451,P＜0.05;JNK1화Livin:r우0.499,P＜0.05;Raf화Livin;r=0.445,P＜0.05).결론 JNK1、Raf-1화Livin재대장관상선류암변과정중가능기일정작용.
Objective To study the possible role of JNK1, Faf-1 and Livin in the carcinogenesis of sporadic colorectal tubular adenoma Methods Immunohistochemical staining was used to detect the expression of JNK1, Raf-1 and Livin proteins in 65 sporadic colorectal tubular adenomaas with dysplasia of varying degrees and 22 colorectal tubular adenoma with cancerous area. Results In normal colorectal mucosa, colorectal tubular adenoma with dysplasia and colorectal tubular adenoma with cancerous area, the positive rate of JNK1, Raf-1 and Livin expression was in creased gradually.The positive expression of JNK1Raf-1 and Livin was all sighificantly higher in the cases of colorectal tubular adenoma with dysplasia or with cancerous area than that in normal colorectal mucosa ( P＜ 0.05), and the positive expression of JNK1, Raf-1and Livin was significantly higher in colorectal tubular adenoina with cancerous area than that in colorectal tubular adenoma with dvsplasia of different degrees (P ＜ 0 05). In the cases of colorectal tubulgr adenomawith dysplasia of varying degrees, the positive expression of Raf-1 was mcreased along with the increaslng dysplasia degrse of colorectal tubular adenoma (P＜0.05). Coexpressior of JNK1, Raf-1 and Livin increased gradually in the careinogenesis of sporadic colorectal tubular adenoma,while positive correlation was found among the expressions of JNK1, Raf-1 and Livin Conclusion JNK1,Raf-1 and Livin may be involved in the carciongenesis of sporadic colorectal tubular adenoma.
