合成化学
閤成化學
합성화학
CHINESE JOURNAL OF SYNTHETIC CHEMISTRY
2010年
1期
90-93
,共4页
魏芬芬%林雅铃%张安强%陈秀云%王炼石
魏芬芬%林雅鈴%張安彊%陳秀雲%王煉石
위분분%림아령%장안강%진수운%왕련석
四臂星形嵌段共聚物%季戊四醇%聚乳酸%聚乙二醇%合成
四臂星形嵌段共聚物%季戊四醇%聚乳痠%聚乙二醇%閤成
사비성형감단공취물%계무사순%취유산%취을이순%합성
four-arm star-shaped block copolymer%pentaerythritol%poly(D,L-lactide)%poly(ethylene glycol)%synthesis
季戊四醇与D,L-丙交酯开环聚合制得末端为羟基的四臂星形聚乳酸(s-PDLLA);s-PDLLA与羧基封端的聚乙二醇单甲醚(CT-mPEG)完成酯化反应,合成了以季戊四醇为核,以聚乳酸为内部嵌段、聚乙二醇为外部嵌段的四臂星形聚(D,L-乳酸)-聚乙二醇嵌段共聚物(s-PDLLA-b-PEG),其结构经~1H NMR,IR和GPC表征.
季戊四醇與D,L-丙交酯開環聚閤製得末耑為羥基的四臂星形聚乳痠(s-PDLLA);s-PDLLA與羧基封耑的聚乙二醇單甲醚(CT-mPEG)完成酯化反應,閤成瞭以季戊四醇為覈,以聚乳痠為內部嵌段、聚乙二醇為外部嵌段的四臂星形聚(D,L-乳痠)-聚乙二醇嵌段共聚物(s-PDLLA-b-PEG),其結構經~1H NMR,IR和GPC錶徵.
계무사순여D,L-병교지개배취합제득말단위간기적사비성형취유산(s-PDLLA);s-PDLLA여최기봉단적취을이순단갑미(CT-mPEG)완성지화반응,합성료이계무사순위핵,이취유산위내부감단、취을이순위외부감단적사비성형취(D,L-유산)-취을이순감단공취물(s-PDLLA-b-PEG),기결구경~1H NMR,IR화GPC표정.
Four-arm star-shaped hydroxyl-terminated poly(D,L-lactide)(s-PDLLA) was prepared by ring-opening polymerization of D,L-lactide initiated by pentaerythritol in the presence of stannous octoate.Four-arm star-shaped poly(D,L-lactide)-block-poly(ethylene glycol) copolymer(s-PDLLA-b-PEG) was synthesized by esterification of s-PDLLA with carboxyl-terminated poly(ethylene glycol) methyl ether(CT-mPEG).The structures were characterized by ~1H NMR,IR and GPC.
