国际儿科学杂志
國際兒科學雜誌
국제인과학잡지
INTERNATIONAL JOURNAL OF PEDIATRICS
2010年
6期
645-647
,共3页
白细胞介素-17%肾脏疾病%细胞因子
白細胞介素-17%腎髒疾病%細胞因子
백세포개소-17%신장질병%세포인자
Interleukin 17%Kidney disease%Cytokine
白细胞介素-17(IL-17)是近年来新发现的Th17细胞分泌的致炎细胞因子,在机体炎症及自身免疫性疾病中发挥重要作用.该文从IL-17及其受体的结构和编码基因、生物学功能、与肾脏疾病的关系等方面进行综述.进一步研究IL-17在肾脏疾病中的作用,将有助于探讨其发病机制,寻找新的治疗靶点.
白細胞介素-17(IL-17)是近年來新髮現的Th17細胞分泌的緻炎細胞因子,在機體炎癥及自身免疫性疾病中髮揮重要作用.該文從IL-17及其受體的結構和編碼基因、生物學功能、與腎髒疾病的關繫等方麵進行綜述.進一步研究IL-17在腎髒疾病中的作用,將有助于探討其髮病機製,尋找新的治療靶點.
백세포개소-17(IL-17)시근년래신발현적Th17세포분비적치염세포인자,재궤체염증급자신면역성질병중발휘중요작용.해문종IL-17급기수체적결구화편마기인、생물학공능、여신장질병적관계등방면진행종술.진일보연구IL-17재신장질병중적작용,장유조우탐토기발병궤제,심조신적치료파점.
Interleukin 17(IL-17) is a novel member of potent proinflammatory cytokines secreted by Th17 cell subset. It plays an important role in inflammatory and autoimmune diseases due to its specific biological functions. This paper reviews the structure and coding gene, biological functions of IL-17, and association with kidney diseases as well. Further studies on the role of IL-17 in kidney diseases will help the understanding about their pathogenesis as well as the search for new treatment targets to these diseases.
