CAJ | 학술논문

探讨艾滋病及其合并隐球菌脑膜炎患者实验室相关指标的变化及其临床意义。方法将我院收治的58例艾滋病患者，分为26例艾滋病患者(单纯感染组)、32例艾滋病合并隐球菌脑膜炎患者(合并感染组)，分别对脑脊液和外周血常规及生化指标、T细胞亚群进行检测，分析两组间实验室检测指标的差异。结果合并感染组的脑脊液蛋白质为(601.28±545.24) mmol/L，高于单纯感染组(t= 0.494，P＞0.05)；合并感染组的脑脊液氯化物和葡萄糖分别为(121.571±5.255) mmol/L和(1.944±0.678) mg/L，低于单纯感染组(t=0.129、1.984，P＞0.05)；合并感染组的外周血淋巴细胞、CD3细胞、CD4细胞、CD8细胞分别为(495.0±141.1)、(479.9±137.4)、(35.1±32.2)、(413.9±104.8)个/μL，均低于单纯感染组，两组比较差异有统计学意义(t=2.236、2.007、2.767、1.997，P＜0.05)。结论艾滋病合并隐球菌脑膜炎患者CD4细胞显著下降，临床上出现CD4细胞计数小于100个/μL，CD3和CD8细胞明显下降或淋巴细胞绝对值明显低值，应重视病原学检验。
탐토애자병급기합병은구균뇌막염환자실험실상관지표적변화급기림상의의。방법장아원수치적58례애자병환자，분위26례애자병환자(단순감염조)、32례애자병합병은구균뇌막염환자(합병감염조)，분별대뇌척액화외주혈상규급생화지표、T세포아군진행검측，분석량조간실험실검측지표적차이。결과합병감염조적뇌척액단백질위(601.28±545.24) mmol/L，고우단순감염조(t= 0.494，P＞0.05)；합병감염조적뇌척액록화물화포도당분별위(121.571±5.255) mmol/L화(1.944±0.678) mg/L，저우단순감염조(t=0.129、1.984，P＞0.05)；합병감염조적외주혈림파세포、CD3세포、CD4세포、CD8세포분별위(495.0±141.1)、(479.9±137.4)、(35.1±32.2)、(413.9±104.8)개/μL，균저우단순감염조，량조비교차이유통계학의의(t=2.236、2.007、2.767、1.997，P＜0.05)。결론애자병합병은구균뇌막염환자CD4세포현저하강，림상상출현CD4세포계수소우100개/μL，CD3화CD8세포명현하강혹림파세포절대치명현저치，응중시병원학검험。
Objective To study the clinic laboratory characters of AIDS with cryptococcus neoformans meningitis coinfection patients. Methods 58 cases of AIDS patients in our hospital were selected. All the cases were divided into two groups, 26 AIDS patients were infection group, while those with meningitis were coinfection group. T lymphncytes,liver function, blood routine test were detected by the immunological, biochemical methods. Results Compared with the infection group, cerebral protein in coinfection group was high[(601.28±545.24) mmol/L, t =0.494, P＞ 0.05], CL and GLU in coinfection group were low[( 121.571 ± 5.255) mmol/L and ( 1.944 ± 0.678) mg/L, t = 0.129, 1.984,P＞0.05]. In coinfection group, the counts of lymphocyte, CD3, CD4, and CD8 were (495.0± 141.1), (479.9±137.4), (35.1 ± 32.2), (413.9 ± 104.8) colls/μL separately. They were all lower than those in control group ( t=2.236, 2.007,2.767,1.997, P ＜ 0.05 ). Conclusiions The counts of CD4 in AID Spatients with cryptococcus neoformans meningitis is significantly decreased, so in the clinical, pathogen detection should be consided to the patients with CD4 ＜ 100/μL, and the CD3 or CD8 decreased obviously.