国际内分泌代谢杂志
國際內分泌代謝雜誌
국제내분비대사잡지
INTERNATIONAL JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2008年
z1期
59-62
,共4页
多囊卵巢综合征%基因%多态性
多囊卵巢綜閤徵%基因%多態性
다낭란소종합정%기인%다태성
Polycystic ovary syndrome%Gene%Polymorphism
多囊卵巢综合征是生育期女性最常见的内分泌紊乱,以无排卵性不孕、高雄激素血症、胰岛素抵抗为特征,与2型糖尿病、血脂异常、心血管疾病、子宫内膜癌相关.国外报道发病率约6.6%,但病因和具体机制还不清楚.目前的观点倾向于多个微效基因与环境因素共同作用引起.其中最为密切的是D19S884,已在3项独立研究中得到证实.其他如钙蛋白酶(CAPN)-10、17α-羟化酶(CYP17)、雄激素受体(AR)、性激素结合球蛋白基因也是潜在的位点.
多囊卵巢綜閤徵是生育期女性最常見的內分泌紊亂,以無排卵性不孕、高雄激素血癥、胰島素牴抗為特徵,與2型糖尿病、血脂異常、心血管疾病、子宮內膜癌相關.國外報道髮病率約6.6%,但病因和具體機製還不清楚.目前的觀點傾嚮于多箇微效基因與環境因素共同作用引起.其中最為密切的是D19S884,已在3項獨立研究中得到證實.其他如鈣蛋白酶(CAPN)-10、17α-羥化酶(CYP17)、雄激素受體(AR)、性激素結閤毬蛋白基因也是潛在的位點.
다낭란소종합정시생육기녀성최상견적내분비문란,이무배란성불잉、고웅격소혈증、이도소저항위특정,여2형당뇨병、혈지이상、심혈관질병、자궁내막암상관.국외보도발병솔약6.6%,단병인화구체궤제환불청초.목전적관점경향우다개미효기인여배경인소공동작용인기.기중최위밀절적시D19S884,이재3항독립연구중득도증실.기타여개단백매(CAPN)-10、17α-간화매(CYP17)、웅격소수체(AR)、성격소결합구단백기인야시잠재적위점.
Polycystic ovary syndrome,characterized by anovulationary infertility,hyperandrogenism,insulin resistance,is the most common endocrinopathy of women in reproductive age.It is related to type 2 diabetes mellitus,dyslipidemia.cardiovascular diseases and carcinoma of endometrium.The incidence is 6.6% reported in abroad,however,the pathogenesis is still unknown.It is thought that mutiple minor genes and environmental factors mutually cause this condition.The most probable gene is D19S884,which has been proved in three independent studies.Others such as CAPN-10,CYP17,androgen receptor(AR),sex hormone binding globulin genes are potential sites.
