CAJ | 학술논문

目的探讨内皮损伤标志物基质金属蛋白酶-9(MMP-9)及血清高敏C反应蛋白(hsCRP)在急性大脑前循环区脑梗死临床进展为恶性大脑中动脉梗死(m-MCAI)的作用机制.方法收集大脑前循环区脑梗死患者90例,其中46例进展为m-MCAI.在患者入院时,以ELISA和免疫比浊法检测患者血浆MMP-9和hsCRP,并结合患者NIHSS评分及早期头颅CT改变进行分析.结果入院时,m-MCAI患者血浆MMP-9(242.0±58.0)ng/ml明显高于非m-MCAI患者(169.0±50.0)ng/ml(P<0.01),m-MCA患音血浆hsCRP(6.25±1.2)mg/ml明显高于非m-MCAI患者(1.55±0.9)mg/ml(P<0.01).结论早期头颅CT检查结果及血浆MMP-9、hsCRP水平增高对预测m-MCAI进程有一定意义.
목적 탐토내피손상표지물기질금속단백매-9(MMP-9)급혈청고민C반응단백(hsCRP)재급성대뇌전순배구뇌경사림상진전위악성대뇌중동맥경사(m-MCAI)적작용궤제.방법 수집대뇌전순배구뇌경사환자90례,기중46례진전위m-MCAI.재환자입원시,이ELISA화면역비탁법검측환자혈장MMP-9화hsCRP,병결합환자NIHSS평분급조기두로CT개변진행분석.결과 입원시,m-MCAI환자혈장MMP-9(242.0±58.0)ng/ml명현고우비m-MCAI환자(169.0±50.0)ng/ml(P<0.01),m-MCA환음혈장hsCRP(6.25±1.2)mg/ml명현고우비m-MCAI환자(1.55±0.9)mg/ml(P<0.01).결론 조기두로CT검사결과급혈장MMP-9、hsCRP수평증고대예측m-MCAI진정유일정의의.
Objective To evaluate the predicting value of the marker of endothelial injury: plasma matrix metalloproteinase-9( MMP-9) and high sensitivity C-reactive protein( hsCRP) level on the progression of acute anterior circulating territory infarction progressing to malignant middle cerebral artery infarction (m-MCAI). Methods 90 patients with acute anterior circulating territory infarction, in which 46 patients progressed to m-MCAI, were collected and sampled consecutively. The plasma MMP-9 and hsCRP of all patients were determined by ELISA and immunotur-bidimetry,respectively,at admission. And the clinical characters and cranial CT features of the patients were analyzed. Results At admission,the plasma MMP-9 level in the patients with m-MCAI(242.0 ±58.0)ng/ml was significantly higher than that in the patients with non m-MCAI( 169.0 ± 50.0) ng/ml( P < 0. 01) ,the plasma hsCRP level in the patients with m-MCAI(6.25 ±1.2) ng/ml was significantly higher than that in the patients with non m-MCAI( 1.55 ± 0.9) mg/ml( P <0. 01).Conclusion The increased level of plasma MMP-9 and hsCRP could be predictors for the m-MCAI proceeding.