CAJ | 학술논문

目的探讨甲状腺功能异常与代谢综合征及其各组分的关系.方法调查10 461名年龄20～90岁的宁波市某石化企业在职和退休员工人群,测定其体重指数、腰围、血压、空腹血糖、血脂谱和甲状腺功能.采用2005年国际糖尿病联盟(IDF)标准诊断代谢综合征.结果 (1)该企业员工甲状腺功能异常和代谢综合征的患病率分别为4.6％和10.2％；(2)有18.1％的员工存在腰围超标并含至少1项代谢异常；(3)TSH降低、正常和升高3组间代谢综合征的患病率差异无统计学意义；(4)代谢综合征5项组分中,经logistic回归分析显示降低的高密度脂蛋白胆固醇(HDL-C)与TSH降低有关(OR=0.313,95％ CI0.184 ～0.530),高甘油三酯与TSH升高有关(OR=0.767,95％CI0.595～0.991)；(5)进一步分析TSH水平与血脂谱的关系,男性仅总胆固醇和HDL-C随TSH降低而降低；女性除载脂蛋白(Al)外,总胆固醇、低密度脂蛋白胆固醇、甘油三酯、载脂蛋白B随TSH升高而逐渐升高,HDL-C在TSH异常组均显著降低.结论甲状腺功能异常与代谢综合征之间未见有显著相关性.甲状腺功能对于代谢综合征各组分的影响,主要表现为血脂谱改变.
목적 탐토갑상선공능이상여대사종합정급기각조분적관계.방법 조사10 461명년령20～90세적저파시모석화기업재직화퇴휴원공인군,측정기체중지수、요위、혈압、공복혈당、혈지보화갑상선공능.채용2005년국제당뇨병련맹(IDF)표준진단대사종합정.결과 (1)해기업원공갑상선공능이상화대사종합정적환병솔분별위4.6％화10.2％；(2)유18.1％적원공존재요위초표병함지소1항대사이상；(3)TSH강저、정상화승고3조간대사종합정적환병솔차이무통계학의의；(4)대사종합정5항조분중,경logistic회귀분석현시강저적고밀도지단백담고순(HDL-C)여TSH강저유관(OR=0.313,95％ CI0.184 ～0.530),고감유삼지여TSH승고유관(OR=0.767,95％CI0.595～0.991)；(5)진일보분석TSH수평여혈지보적관계,남성부총담고순화HDL-C수TSH강저이강저；녀성제재지단백(Al)외,총담고순、저밀도지단백담고순、감유삼지、재지단백B수TSH승고이축점승고,HDL-C재TSH이상조균현저강저.결론 갑상선공능이상여대사종합정지간미견유현저상관성.갑상선공능대우대사종합정각조분적영향,주요표현위혈지보개변.
Objective To study the relationship between the prevalence of thyroid dysfunction and components of metabolic syndrome.Methods A total of 10 461 working and retired employees aged 20 to 90 years in a Petrochemical Corporation in Ningbo were included.Body mass index ( BMI),waist circumference,blood pressure,fasting blood glucose,blood lipid profile,serum thyroid-stimulating hormone (TSH),free thyroxine ( FT4 ),and free triiodothyronine (FT3 ) were measured in all subjects. Metabolic syndrome was diagnosed according to the International Diabetes Federation(IDF) criteria.Results ( 1 ) The prevalences of metabolic syndrome and overall thyroid dysfunction were 10.2％ and 4.6％,respectively. ( 2 ) 18.1％ petrochemical employees had abdominal obesity with at least one component of metabolic syndrome.( 3 ) There was no significant difference in the prevalence of metabolic syndrome among the groups with lowered,normal,and elevated TSH. (4) Logistic regression analysis revealed that lowered high density lipoprotein cholesterol ( HDL-C ) was associated with lowered TSH ( OR =0.313,95％ CI 0.184-0.530 ),and raised triglyceride was associated with elevated TSH ( OR =0.767,95％ CI 0.595-0.991 ). ( 5 ) There were significant associations between serum TSH levels and lipid parameters such as total cholesterol in males,triglyceride and low density lipoprotein cholesterol in females,and HDL-C in both genders.Conclusion The prevalence of thyroid dysfunction was not associated with central obesity,hypertension,and hyperglycemia.Lipid disorder was correlated with serum TSH levels.