中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2008年
6期
770-771
,共2页
王淳良%梅金红%王珊珊%徐林林%秦兴义
王淳良%梅金紅%王珊珊%徐林林%秦興義
왕순량%매금홍%왕산산%서림림%진흥의
脑膜瘤%微血管密度%血管内皮生长因子%复发
腦膜瘤%微血管密度%血管內皮生長因子%複髮
뇌막류%미혈관밀도%혈관내피생장인자%복발
Menlngoma%Microvesssel density%Vascular endothelial growth factor%Recurrence
目的 探讨脑膜瘤复发与微血管密度(MVD)、血管内皮生长因子(VEGF)的表达与其复发的相关性.方法 采用免疫组织化学MaxVisionTM法,分别检测复发组脑膜瘤33例和非复发组脑膜瘤26例的MVD和VEGF的表达,分析肿瘤复发与两者的关系.结果 非复发组与复发组脑膜瘤的MVD平均值分别为34.2923±17.2422、71.410±39.475,复发组明显高于非复发组(P<0.05);其中复发组脑膜瘤I级与Ⅱ、Ⅲ级的MVD平均值分别为54.7304±25.3080、109.780±39.642,Ⅱ、Ⅲ级的MVD平均值明显高于I级者(P<0.05).VEGF蛋白表达在复发组脑膜瘤I级的阳性率39.13%(9/23)高于非复发组的阳性率11.54%(3/26)(P<0.05).38例VEGF蛋白表达阴性的脑膜瘤中MVD平均值为37.9263±15.2300,21例VEGF蛋白表达阳性的脑膜瘤中MVD平均值为86.0286±28.7464,VEGF蛋白的表达与MVD平均值呈正相关(r=0.7888,P<0.05). 结论 VEGF和MVD联合检测可作为反映脑膜瘤临床病理特征的指标之一,两者高水平的表达提示复发的可能性较大.
目的 探討腦膜瘤複髮與微血管密度(MVD)、血管內皮生長因子(VEGF)的錶達與其複髮的相關性.方法 採用免疫組織化學MaxVisionTM法,分彆檢測複髮組腦膜瘤33例和非複髮組腦膜瘤26例的MVD和VEGF的錶達,分析腫瘤複髮與兩者的關繫.結果 非複髮組與複髮組腦膜瘤的MVD平均值分彆為34.2923±17.2422、71.410±39.475,複髮組明顯高于非複髮組(P<0.05);其中複髮組腦膜瘤I級與Ⅱ、Ⅲ級的MVD平均值分彆為54.7304±25.3080、109.780±39.642,Ⅱ、Ⅲ級的MVD平均值明顯高于I級者(P<0.05).VEGF蛋白錶達在複髮組腦膜瘤I級的暘性率39.13%(9/23)高于非複髮組的暘性率11.54%(3/26)(P<0.05).38例VEGF蛋白錶達陰性的腦膜瘤中MVD平均值為37.9263±15.2300,21例VEGF蛋白錶達暘性的腦膜瘤中MVD平均值為86.0286±28.7464,VEGF蛋白的錶達與MVD平均值呈正相關(r=0.7888,P<0.05). 結論 VEGF和MVD聯閤檢測可作為反映腦膜瘤臨床病理特徵的指標之一,兩者高水平的錶達提示複髮的可能性較大.
목적 탐토뇌막류복발여미혈관밀도(MVD)、혈관내피생장인자(VEGF)적표체여기복발적상관성.방법 채용면역조직화학MaxVisionTM법,분별검측복발조뇌막류33례화비복발조뇌막류26례적MVD화VEGF적표체,분석종류복발여량자적관계.결과 비복발조여복발조뇌막류적MVD평균치분별위34.2923±17.2422、71.410±39.475,복발조명현고우비복발조(P<0.05);기중복발조뇌막류I급여Ⅱ、Ⅲ급적MVD평균치분별위54.7304±25.3080、109.780±39.642,Ⅱ、Ⅲ급적MVD평균치명현고우I급자(P<0.05).VEGF단백표체재복발조뇌막류I급적양성솔39.13%(9/23)고우비복발조적양성솔11.54%(3/26)(P<0.05).38례VEGF단백표체음성적뇌막류중MVD평균치위37.9263±15.2300,21례VEGF단백표체양성적뇌막류중MVD평균치위86.0286±28.7464,VEGF단백적표체여MVD평균치정정상관(r=0.7888,P<0.05). 결론 VEGF화MVD연합검측가작위반영뇌막류림상병리특정적지표지일,량자고수평적표체제시복발적가능성교대.
Objective To study the relativity of the microvesssel density (MVD) and the expression of vascular endothelial growth factor (VEGF) and meningioma recurrence.Methods In 33 cases of recurrent meningiomas (recurrence group) and 26 cases of primary meningiomas (non-recurrence group),the expression of MVD and VEGF was detected by using immunohistochemistry MaxVisionTM,and the relationship of MVD and VEGF with recurrence of meningoma was analyzed.Results The average MVD in non-recurrence group and recurrence group was 34.2923±17.2422 and 71.410±39.475 respectively (P<0.05).In recurrence group,the average MVD was 54.7304±25.3080 and 109.780±39.642 in the recurrent meningiomas of grade Ⅰ and grade Ⅱ,Ⅲ respectively (P<0.05).The expression of VEGF was 39.13% (9/23) and 11.54% (3/26) in the recurrent meningiomas of grade Ⅰ and primary meningiomas,respectively (P<0.05).The average MVD was 37.9263±15.2300 in 38 meningiomas negative for the expression of VEGF,and 86.0286±28.7464 in 21 meningiomas positive for the expression of VEGF respectively.The expression of VEGF was positively correlated with the average MVD (r=0.7888,P<0.05).Conclusion Combined detection of VEGF and MVD can be regarded as one of the objective indexes reflecting clinical trials of meningoma.The higher expression of VEGF and MVD expression suggests the greater probability of recurrence.
