CAJ | 학술논문

目的揭示娄底市麻疹IgM抗体的分布特征,探讨该市麻疹相对高发的主要原因.方法采集麻疹疑似病例血清标本用ELISA法检测IgM抗体,全部数据录入MS Excel并用SPSS软件进行分析.结果 308份合格血清IgM总阳性率为50.99%,其中按要求完整填写相关信息的219份,标本总阳性率为49.32%;按有明确免疫史、无免疫史和免疫史不详分3组统计,其阳性率分别为38.46%,46.52%和52%,3组阳性率无统计学差异(χ2=1.793 0,P=0.408 0);按采样时间分组统计,出疹后5～10日采样检测阳性率显著高于其他组(χ2=16.967 0,P＜0.000 1),对其中麻疹IgM阴性的34份血清做风疹IgM检测,结果仅有4份显示弱阳性.结论麻疹IgM检测采样的最佳时间为出疹后5～10日;免疫空白人群和原始免疫失败为本市麻疹感染发病的主要影响因素.
목적 게시루저시마진IgM항체적분포특정,탐토해시마진상대고발적주요원인.방법 채집마진의사병례혈청표본용ELISA법검측IgM항체,전부수거록입MS Excel병용SPSS연건진행분석.결과 308빈합격혈청IgM총양성솔위50.99%,기중안요구완정전사상관신식적219빈,표본총양성솔위49.32%;안유명학면역사、무면역사화면역사불상분3조통계,기양성솔분별위38.46%,46.52%화52%,3조양성솔무통계학차이(χ2=1.793 0,P=0.408 0);안채양시간분조통계,출진후5～10일채양검측양성솔현저고우기타조(χ2=16.967 0,P＜0.000 1),대기중마진IgM음성적34빈혈청주풍진IgM검측,결과부유4빈현시약양성.결론 마진IgM검측채양적최가시간위출진후5～10일;면역공백인군화원시면역실패위본시마진감염발병적주요영향인소.
Objective To reveal the distribution characteristics of measles IgM and their implication for measles control in Loudi City. Methods Samples from suspected measles cases were tested by measles IgM-capture ELISA and results were analyzed using MS Excel and SPSS software package. Results Total IgM positive rate was 50.99% for the 308 adequate samples submitted to the city CDC laboratory and that for the 219 samples that met the information requests for detailed analysis was 49.32%.Of the 219 samples,positive rates were 38.46%,46.52% and 52% for the groups of cases: (1) vaccinated,(2 ) unvaccinated and (3) no documented vaccination,respectively,showing no statistical differences(χ2=1.793 0,P=0.408 0),and positive rates were significantly higher(χ2=16.967 0,P＜0.000 1)for the group of samples taken between 5-10 days post rash onset.Only 4 showed weak positive results when 34 measles IgM-negative sera were tested for differential diagnosis from rubella.Conclusions The optimum sampling time for measles IgM detection was 5-10 days post rash onset.Gaps in population immunity and primary failures in immunization were principle factors leading to measles infection and epidemic in Loudi City.