国际生物医学工程杂志
國際生物醫學工程雜誌
국제생물의학공정잡지
INTERNATIONAL JOURNAL OF BIOMEDICAL ENGINEERING
2012年
1期
61-64
,共4页
LRRFIP1%肿瘤%转录抑制%缺血性脑血管病
LRRFIP1%腫瘤%轉錄抑製%缺血性腦血管病
LRRFIP1%종류%전록억제%결혈성뇌혈관병
Leucine-richrepeat(in FLⅡ)interactingprotein 1%Tumor,Transcription inhibition%Ischemic cerebrovascular disease
富含亮氨酸重复序列相互作用蛋白1 (LRRFIP1)是一种转录抑制因子,存在于多种动物和人的组织细胞中,在表皮生长、肿瘤及脑血管病中表达明显升高,具有转录抑制作用、参与信号通路调控及参与血小板细胞骨架的组成部分,也是miRNA调节的靶基因,并起着重要作用.对LRRFIP1的结构特点、分布与功能及其机制进行综述.
富含亮氨痠重複序列相互作用蛋白1 (LRRFIP1)是一種轉錄抑製因子,存在于多種動物和人的組織細胞中,在錶皮生長、腫瘤及腦血管病中錶達明顯升高,具有轉錄抑製作用、參與信號通路調控及參與血小闆細胞骨架的組成部分,也是miRNA調節的靶基因,併起著重要作用.對LRRFIP1的結構特點、分佈與功能及其機製進行綜述.
부함량안산중복서렬상호작용단백1 (LRRFIP1)시일충전록억제인자,존재우다충동물화인적조직세포중,재표피생장、종류급뇌혈관병중표체명현승고,구유전록억제작용、삼여신호통로조공급삼여혈소판세포골가적조성부분,야시miRNA조절적파기인,병기착중요작용.대LRRFIP1적결구특점、분포여공능급기궤제진행종술.
leucine-rich repeat (in FLⅡ) interacting protein 1(LRRFIP1) is a kind of transcription inhibitory factor which exists in tissue cells of various animals and human body.Its expression increases significantly in epidermal growth,tumors and cerebrovascular diseases.With transcription inhibition feature,it involves in the regulation of signal pathways and the platelet cytoskeleton component.It is also target gene of miRNA regulation and plays an important role in the process.This paper reviews the LRRFIP1 structure characteristics,distribution and function and its regulation mechanism.
