中华放射肿瘤学杂志
中華放射腫瘤學雜誌
중화방사종류학잡지
CHINESE JOURNAL OF RADIATION ONCOLOGY
2009年
1期
37-41
,共5页
刘青%王雅棣%董稚明%王晓玲%景尚华
劉青%王雅棣%董稚明%王曉玲%景尚華
류청%왕아체%동치명%왕효령%경상화
鼻咽肿瘤%锰超氧化物歧化酶%钙黏蛋白%放射敏感性%预后
鼻嚥腫瘤%錳超氧化物歧化酶%鈣黏蛋白%放射敏感性%預後
비인종류%맹초양화물기화매%개점단백%방사민감성%예후
Nasopharyngeal neoplasms%Manganese superoxide dismutase%E-cadherin%Ra diosentivity%Prognosis
目的 观察锰超氧化物歧化酶(MnSOD)和E-钙黏蛋白(E-Cad)在鼻咽癌组织中的表达及其生物学意义.方法 应用免疫组织化学S-P法,对60例鼻咽癌组织中MnSOD及E-Cad的表达水平进行检测和评价.结果 MnSOD强阳性表达率全组的为47%(28例),淋巴结阳性者(51例)中的为49%(25例),淋巴结阴性者(9例)中的为33%(3例)(x2=0.76,P=0.382).E-Cad强阳性表达率全组的为47%(28例),淋巴结阳性者中的为43%(22例),淋巴结阴性者中的为78%(7例)(x2=3.69,P=0.047).随T、N分期增加MnSOD表达水平上升,且仅与转移淋巴结大小呈正相关(r=0.46,P=0.002),与淋巴结转移区域无关(r=0.22,P=0.116);MnSOD高表达时放射敏感性低、疗效差.E-Cad表达越低N分期越晚,其表达水平与淋巴结转移区域呈负相关(r=0.33,P=0.020),但与T分期、转移淋巴结大小及放射敏感性无关(r=-2.19,P=0.093;r=-0.07,P=0.623;r=-0.18,P=0.170).多因素分析显示MnSOD、E-Cad表达水平升高与预后生存有关(x2=4.45,P=0.035;x2=5.12,P=0.024).结论 MnSOD高表达可能促进肿瘤生长,降低鼻咽癌放射敏感性.ECad高表达可抑制癌细胞淋巴转移,但与肿瘤生长、浸润无关.MnSOD、E-Cad表达水平有可能影响鼻咽癌预后.
目的 觀察錳超氧化物歧化酶(MnSOD)和E-鈣黏蛋白(E-Cad)在鼻嚥癌組織中的錶達及其生物學意義.方法 應用免疫組織化學S-P法,對60例鼻嚥癌組織中MnSOD及E-Cad的錶達水平進行檢測和評價.結果 MnSOD彊暘性錶達率全組的為47%(28例),淋巴結暘性者(51例)中的為49%(25例),淋巴結陰性者(9例)中的為33%(3例)(x2=0.76,P=0.382).E-Cad彊暘性錶達率全組的為47%(28例),淋巴結暘性者中的為43%(22例),淋巴結陰性者中的為78%(7例)(x2=3.69,P=0.047).隨T、N分期增加MnSOD錶達水平上升,且僅與轉移淋巴結大小呈正相關(r=0.46,P=0.002),與淋巴結轉移區域無關(r=0.22,P=0.116);MnSOD高錶達時放射敏感性低、療效差.E-Cad錶達越低N分期越晚,其錶達水平與淋巴結轉移區域呈負相關(r=0.33,P=0.020),但與T分期、轉移淋巴結大小及放射敏感性無關(r=-2.19,P=0.093;r=-0.07,P=0.623;r=-0.18,P=0.170).多因素分析顯示MnSOD、E-Cad錶達水平升高與預後生存有關(x2=4.45,P=0.035;x2=5.12,P=0.024).結論 MnSOD高錶達可能促進腫瘤生長,降低鼻嚥癌放射敏感性.ECad高錶達可抑製癌細胞淋巴轉移,但與腫瘤生長、浸潤無關.MnSOD、E-Cad錶達水平有可能影響鼻嚥癌預後.
목적 관찰맹초양화물기화매(MnSOD)화E-개점단백(E-Cad)재비인암조직중적표체급기생물학의의.방법 응용면역조직화학S-P법,대60례비인암조직중MnSOD급E-Cad적표체수평진행검측화평개.결과 MnSOD강양성표체솔전조적위47%(28례),림파결양성자(51례)중적위49%(25례),림파결음성자(9례)중적위33%(3례)(x2=0.76,P=0.382).E-Cad강양성표체솔전조적위47%(28례),림파결양성자중적위43%(22례),림파결음성자중적위78%(7례)(x2=3.69,P=0.047).수T、N분기증가MnSOD표체수평상승,차부여전이림파결대소정정상관(r=0.46,P=0.002),여림파결전이구역무관(r=0.22,P=0.116);MnSOD고표체시방사민감성저、료효차.E-Cad표체월저N분기월만,기표체수평여림파결전이구역정부상관(r=0.33,P=0.020),단여T분기、전이림파결대소급방사민감성무관(r=-2.19,P=0.093;r=-0.07,P=0.623;r=-0.18,P=0.170).다인소분석현시MnSOD、E-Cad표체수평승고여예후생존유관(x2=4.45,P=0.035;x2=5.12,P=0.024).결론 MnSOD고표체가능촉진종류생장,강저비인암방사민감성.ECad고표체가억제암세포림파전이,단여종류생장、침윤무관.MnSOD、E-Cad표체수평유가능영향비인암예후.
Objective To investigate the expression of MnSOD and E-cadhefin in nasopharyngeal carcinoma(NPC) tissue and its relationship with clinicopathological features and prognosis. Methods The expression of MnSOD and E-cadherin were detected by immunohistochemistry method in 60 NPC patients. Results Of the whole group,lymph node positive group and lymph node negative group,the strong positive rate of MnSOD protein was 47% (28/60) ,49% (25/51 patients) and 33% (3/9) (x2 =0.76,P =0.382), respectively.The corresponding strong positive rate of E-cadherin protein was 47% (28/60) ,43% (22/51) and 78% (7/9) (x2 =3.69,P =0.047) ,respectively.The expression of MnSOD increased with T stage and N stage.The higher expression of MnSOD was significantly associated with the larger size of metastatic lymph node(r =0.46 ,P =0.002) ,more radioresistance and poorer prognosis,but not with the region of lymph node metastasis(r =0.223,P = 0.116).The lower expression of E-cadherin was closely relevant with higher N stage and the smaller region of lymph node metastasis(r =-0.33,P = 0.020),but not with T stage,lymph node size or radiosensitivity(r =-2.19,P=0.093;r=-0.07,P=0.623;r=-0.18,P=0.170).Multi variate analysis showed that MnSOD and E-canherin were independent prognostic factors (x2= 4.45,P = 0.035;x2 =5.12,P=0.024). Conclusions High expression of MnSOD may stimulate tumor growth and reduce radiosensitivity.High expression of E-cadherin may inhibit lymphatic metastasis,while has no rela tionship with tumor growth and invasion.MnSOD and E-cadherin could affect the prognosis of NPC patients.
