中华内分泌代谢杂志
中華內分泌代謝雜誌
중화내분비대사잡지
CHINESE JOURNAL OF ENDOCRINOLOGY AND METABOLISM
2012年
3期
231-234
,共4页
刘慧蔷%裴丽娜%都健%杨晶%张盈妍
劉慧薔%裴麗娜%都健%楊晶%張盈妍
류혜장%배려나%도건%양정%장영연
胰岛素抵抗%vaspin%二甲双胍%正常血糖-高胰岛素钳夹技术%大鼠
胰島素牴抗%vaspin%二甲雙胍%正常血糖-高胰島素鉗夾技術%大鼠
이도소저항%vaspin%이갑쌍고%정상혈당-고이도소겸협기술%대서
Insulin resistance%Vaspin%Metformin%Euglycemic-hyperinsulinemic clamp%Rats
采用高脂喂养并利用清醒状态下正糖-高胰岛素钳夹技术评估胰岛素抵抗大鼠模型.胰岛素抵抗大鼠脂肪组织vaspin mRNA表达量明显低于对照组(P＜0.05),二甲双胍治疗后表达升高(P＜0.05),提示二甲双胍在改善大鼠胰岛素抵抗状态的同时能上调胰岛素抵抗大鼠内脏脂肪组织vaspin mRNA的表达.
採用高脂餵養併利用清醒狀態下正糖-高胰島素鉗夾技術評估胰島素牴抗大鼠模型.胰島素牴抗大鼠脂肪組織vaspin mRNA錶達量明顯低于對照組(P＜0.05),二甲雙胍治療後錶達升高(P＜0.05),提示二甲雙胍在改善大鼠胰島素牴抗狀態的同時能上調胰島素牴抗大鼠內髒脂肪組織vaspin mRNA的錶達.
채용고지위양병이용청성상태하정당-고이도소겸협기술평고이도소저항대서모형.이도소저항대서지방조직vaspin mRNA표체량명현저우대조조(P＜0.05),이갑쌍고치료후표체승고(P＜0.05),제시이갑쌍고재개선대서이도소저항상태적동시능상조이도소저항대서내장지방조직vaspin mRNA적표체.
High-fat diet-induced insulin resistance rat model was assessed by euglycemic-hyperinsulinemic clamp technique.Compared with the control group,the vaspin mRNA expression in adipose tissue was significantly decreased in insulin resistant rats induced by high-fat diet( P＜0.05 ),which was increased by metformin( P＜0.05 ).These data indicate that metformin may ameliorate insulin resistance in rats via upregulating vaspin mRNA expression.
