CAJ | 학술논문

目的检测心力衰竭的患者中血浆N末端B型钠尿肽(NT-proBNP)和高敏C反应蛋白(hs-CRP)的水平变化,探讨心力衰竭患者血NT-proBNP与hs-CRP的相关性及其在心力衰竭患者预后的临床意义.方法 2009年1至10月随机选择上海交通大学医学院附属仁济医院嘉定分院急诊科100例心力衰竭的患者和与之年龄、性别等相匹配的20名对照者进入本研究.酶联免疫吸附法测定血清NT-proBNP水平,免疫比浊法测定hs-CRP水平.结果心力衰竭组患者的血NT-proBNP水平均明显高于对照组患者,差异均有统计学意义(均P<0.01).心力衰竭患者中血NT-proBNP水平升高程度与同期测定的血hs-CRP水平呈显著正相关.结论 ①血NT-proBNP水平在心力衰竭患者中明显升高,可作为辅助诊断指标之一.②NT-proBNP结合hs-CRP的水平可预测心力衰竭患者的预后.
목적 검측심력쇠갈적환자중혈장N말단B형납뇨태(NT-proBNP)화고민C반응단백(hs-CRP)적수평변화,탐토심력쇠갈환자혈NT-proBNP여hs-CRP적상관성급기재심력쇠갈환자예후적림상의의.방법 2009년1지10월수궤선택상해교통대학의학원부속인제의원가정분원급진과100례심력쇠갈적환자화여지년령、성별등상필배적20명대조자진입본연구.매련면역흡부법측정혈청NT-proBNP수평,면역비탁법측정hs-CRP수평.결과 심력쇠갈조환자적혈NT-proBNP수평균명현고우대조조환자,차이균유통계학의의(균P<0.01).심력쇠갈환자중혈NT-proBNP수평승고정도여동기측정적혈hs-CRP수평정현저정상관.결론 ①혈NT-proBNP수평재심력쇠갈환자중명현승고,가작위보조진단지표지일.②NT-proBNP결합hs-CRP적수평가예측심력쇠갈환자적예후.
Objective To detect the level changes of plasma N-terminal B-type natriuretic peptide (NT-proBNP)and hish-sensitivity C-reactive protein(hs-CRP)in patients with heart failure(HF)and explore their clinical correlations and prognostic significances.Methods A total of 100 cases of HF patients were selected along with 20 age and gender-matched controls.The levels of NT-proBNP and hs-CRP were tested.Results The levels of NT-proBNP were significantly higher in HF patients than the controls.And the difference was statistically significant(P<0.01).In congestive HF patients,the elevating magnitude of plasma NT-proBNP level showed a significantly positive correlation with that of hs-CRP during the same period.Conclusion ①The level of NT-proBNP is significantly higher in HF patients.And it can be used as one of auxiliary diagnostic indieators.②The level of NT-proBNP in conjunction with hs-CRP can predict the prognosis of HF patients.