中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2012年
13期
15-16
,共2页
肝肾综合征%肝功能衰竭%治疗结果
肝腎綜閤徵%肝功能衰竭%治療結果
간신종합정%간공능쇠갈%치료결과
Hepatorenal syndrome%Liver failure%Treatment outcome
目的 探讨肝肾综合征(HRS)患者的临床特点,指导临床对HRS进行有效地预防和治疗.方法 回顾性分析72例HRS患者的临床资料,比较HRS发生前后血清钠(Na+)、肌酐(cr)、白蛋白(ALB)和凝血酶原活动度(PTA)的变化情况.结果 HRS多发于40～59岁男性,主要发生于乙型肝炎所致的肝硬化,肝功能绝大多数处于Child-Pugh C级,病死率高.大量腹水、继发感染、上消化道出血、大量放腹水可诱发HRS.HRS发生前后患者血清Na+、Cr、ALB和PTA的变化显著(P＜0.05).结论 HRS患者的病情重,病死率高,预后差,要重视对肝肾综合征的临床研究.HRS患者肝功能差,血清Na+、ALB和PTA降低,血清Cr升高,常见诱因为大量腹水、继发感染、上消化道出血、大量放腹水,应尽量避免,发现后应积极治疗.
目的 探討肝腎綜閤徵(HRS)患者的臨床特點,指導臨床對HRS進行有效地預防和治療.方法 迴顧性分析72例HRS患者的臨床資料,比較HRS髮生前後血清鈉(Na+)、肌酐(cr)、白蛋白(ALB)和凝血酶原活動度(PTA)的變化情況.結果 HRS多髮于40～59歲男性,主要髮生于乙型肝炎所緻的肝硬化,肝功能絕大多數處于Child-Pugh C級,病死率高.大量腹水、繼髮感染、上消化道齣血、大量放腹水可誘髮HRS.HRS髮生前後患者血清Na+、Cr、ALB和PTA的變化顯著(P＜0.05).結論 HRS患者的病情重,病死率高,預後差,要重視對肝腎綜閤徵的臨床研究.HRS患者肝功能差,血清Na+、ALB和PTA降低,血清Cr升高,常見誘因為大量腹水、繼髮感染、上消化道齣血、大量放腹水,應儘量避免,髮現後應積極治療.
목적 탐토간신종합정(HRS)환자적림상특점,지도림상대HRS진행유효지예방화치료.방법 회고성분석72례HRS환자적림상자료,비교HRS발생전후혈청납(Na+)、기항(cr)、백단백(ALB)화응혈매원활동도(PTA)적변화정황.결과 HRS다발우40～59세남성,주요발생우을형간염소치적간경화,간공능절대다수처우Child-Pugh C급,병사솔고.대량복수、계발감염、상소화도출혈、대량방복수가유발HRS.HRS발생전후환자혈청Na+、Cr、ALB화PTA적변화현저(P＜0.05).결론 HRS환자적병정중,병사솔고,예후차,요중시대간신종합정적림상연구.HRS환자간공능차,혈청Na+、ALB화PTA강저,혈청Cr승고,상견유인위대량복수、계발감염、상소화도출혈、대량방복수,응진량피면,발현후응적겁치료.
[Objective] To investigate the clinical features of hepatorenal syndrome(RSH),and to guide the effective prevention and treatment of the disease.[Methods] The clinical data of 72 patients with RSH were retrospectively analyzed,the changes of serum sodium,creatinine(Cr),albumin(ALB)and prothrombin activity(PTA)were compared before and after the occurrence of RSH.[Results] HRS was more prevalent among males aged 40-59 and patients with cirrhosis caused by hepatitis B,the vast majority of liver function in a Child-Pugh C level,and with high mortality.Massive ascites,secondary infection,upper gastrointestinal bleeding and releasing a large number of ascites could induce the occurrence of HRS.The serum sodium,Cr,ALB and PTA changed significantly before and after the occurrence of RSH(P＜0.05).[Conclusions] Patients with HSR have serious conditions,high mortality and the prognosis is poor,so we should pay attention to the clinical research of HSR.The patients with HRS have poor liver function,reduced serum sodium,ALB and PTA,increased serum Cr.The common predisposing factor of HRS including massive ascites,secondary infection,upper gastrointestinal bleeding and releasing a large number of ascites,we should avoid these factors as far as possible,once happened we should take active treatment.
