CAJ | 학술논문

研究人参皂甙Re对神经内分泌系统的保护作用.采用高效液相色谱检测法测定水浸-束缚应激大鼠脑内单胺类递质和血清皮质酮的含量.水浸-束缚应激模型能使大鼠额叶、纹状体、下丘脑三个脑区的单胺类递质及其代谢产物(去甲肾上腺素、多巴胺、高香草酸、5-羟色胺、5-羟吲哚乙酸)和血清皮质酮的含量明显增高.预先给予人参皂甙Re(4.5和9 mg/kg,ig)后均有不同程度的降低,并呈一定的量效关系.结果表明人参皂甙Re具有一定的神经保护作用.
연구인삼조대Re대신경내분비계통적보호작용.채용고효액상색보검측법측정수침-속박응격대서뇌내단알류체질화혈청피질동적함량.수침-속박응격모형능사대서액협、문상체、하구뇌삼개뇌구적단알류체질급기대사산물(거갑신상선소、다파알、고향초산、5-간색알、5-간신타을산)화혈청피질동적함량명현증고.예선급여인삼조대Re(4.5화9 mg/kg,ig)후균유불동정도적강저,병정일정적량효관계.결과표명인삼조대Re구유일정적신경보호작용.
To investigate the effect of ginsenoside Re on the function of the neuroendocrine system,in water immersion-restraint rats,the contents of brain monoamines transmitters and serum corticosterone were evaluated using high performance liquid chromatography. There was a significant increase of content of brain monoamines transmitters and their metabolites, noradrenaline(NA) , dopamine( DA) , 5-hydroxytryptamine (5-HT) , homovanillic acid( HVA) , 5-hydroxyin-dole-3-acetic acid(5-HIAA) ,and serum corticosterone in pallium,striatum.hypothalamus of water immersion-restraint rats. The elevated level was markedly and dose-dependently reduced by ginsenoside Re(3,6 and 9 mg · kg~(-1)). The data indicated that ginsenoside Re possesses significant effect of recovering the marked increase of neurotransmitters induced by water immersion-restraint stress. This study demonstrates the neuroprotective potential of ginsenoside Re in water immersion-restraint rats.