CAJ | 학술논문

硫氧还蛋白还原酶(TrxR)是巯基调节系统中重要的组成部分,其C末端的硒代半胱氨酸残基是催化位点,可与各类底物和抑制剂相结合.许多肿瘤细胞均高表达TrxR,其在肿瘤耐药方面也起着重要作用.大量天然和人工合成的TrxR抑制剂均有抗癌作用,可以诱导应激反应,导致细胞周期停滞,甚至引起凋亡,可单独、联合或辅助用于肿瘤治疗.
류양환단백환원매(TrxR)시구기조절계통중중요적조성부분,기C말단적서대반광안산잔기시최화위점,가여각류저물화억제제상결합.허다종류세포균고표체TrxR,기재종류내약방면야기착중요작용.대량천연화인공합성적TrxR억제제균유항암작용,가이유도응격반응,도치세포주기정체,심지인기조망,가단독、연합혹보조용우종류치료.
Thioredoxin reductase(TrxR) is an important component of thiol regulating system and contains a reactive and solvent accessible selenocysteine residue which is located on a flexible C-terminal arm of the protein and can combine various substrates and inhibitors. Many tumor cells have elevated TrxR levels and TrxR has also been shown to play a major role in drug resistance. A great number of effective natural and synthetic TrxR inhibitors are now availably possessing antitumor potential through induction of oxidative stress, cell cycle arrest and apoptosis. Inhibitors of TrxR may thus contribute to a successfully single, combinatory or adjuvant cancer therapy.