CAJ | 학술논문

目的掌握陕西省饮水型地方性砷中毒病情程度及特征,为防治工作提供依据.方法 2009年在已查明的商洛、汉中2个市饮水型砷中毒病区和饮水含砷量＞0.15 mg/L的潜在砷中毒病区,选择山阳县的杜河村、庙沟村、三合村、蔡园村和镇安县的双龙村、光明村、东河口村以及勉县的郭家湾村共8个自然村作为监测点.对连续居住半年以上的居民,按照<地方性砷中毒诊断标准>(WS/T 211-2001)进行砷中毒病情调查;同时采集监测点水样,测定饮水含砷量.结果 8个村共调查7693人,查出砷中毒患者612人,检出率为7.96%(612/7693),其中轻度患者占33.17%(203/612)、中度患者占50.16%(307/612)、重度患者占16.67%(102/612).男性检出率为9.99%(408/4085),女性检出率为5.65%(204/3608),男性检出率高于女性(x2=49.138,P＜0.01).年龄越大,砷中毒检出率越高(x2=770.708,P＜0.01).患者的临床表现主要为皮肤色素脱失和皮肤色素沉着,单体症病例占43.30%(265/612),双体症病例占56.70%(347/612).共检测水样370份,水砷中位数为0.005 mg/L,范围为0～1.660 mg/L,水砷超标率为11.62%(43/370).结论陕西省饮水型地方性砷中毒病情程度总体上为轻度,但防治监测工作还需重视.
목적 장악합서성음수형지방성신중독병정정도급특정,위방치공작제공의거.방법 2009년재이사명적상락、한중2개시음수형신중독병구화음수함신량＞0.15 mg/L적잠재신중독병구,선택산양현적두하촌、묘구촌、삼합촌、채완촌화진안현적쌍룡촌、광명촌、동하구촌이급면현적곽가만촌공8개자연촌작위감측점.대련속거주반년이상적거민,안조<지방성신중독진단표준>(WS/T 211-2001)진행신중독병정조사;동시채집감측점수양,측정음수함신량.결과 8개촌공조사7693인,사출신중독환자612인,검출솔위7.96%(612/7693),기중경도환자점33.17%(203/612)、중도환자점50.16%(307/612)、중도환자점16.67%(102/612).남성검출솔위9.99%(408/4085),녀성검출솔위5.65%(204/3608),남성검출솔고우녀성(x2=49.138,P＜0.01).년령월대,신중독검출솔월고(x2=770.708,P＜0.01).환자적림상표현주요위피부색소탈실화피부색소침착,단체증병례점43.30%(265/612),쌍체증병례점56.70%(347/612).공검측수양370빈,수신중위수위0.005 mg/L,범위위0～1.660 mg/L,수신초표솔위11.62%(43/370).결론 합서성음수형지방성신중독병정정도총체상위경도,단방치감측공작환수중시.
Objective To know the condition and feature of water-born endemic arsenism in Shaanxi province, and to provide scientific evidences for prevention and treatment of the disease. Methods In 2009, 8 villages of Duhe, Miaogou, Sanhe, Caiyuan in Shanyang county and Shuanglong, Guangming, Donghekou in Zhen'an county and Guojiawan in Mian county as monitoring sites from both the found water-born arsenic poisoning areas and potential ones of drinking water arsenic ＞ 0.15 mg/L were selected. The disease conditions of residents who lived for more than six months of continuous residence, were investigated according to "Endemic Arsenism Diagnostic Criteria" (WS/T 211-2001 ) and arsenic level in the drinking water were determined. Results Seven thousand six hundred and ninety-three individuals were investigated and 612 cases of arsenism were diagnosed in the 8 villages, the prevalence rate was 7.96%(612/7693). Mild patients accounted for 33.17%(203/612), moderate patients accounted for 50.16%(307/612), and severe patients accounted for 16.67%(102/612). The detection rate for male was 9.99%(408/4085), for female was 5.65%(204/3608), the former was higher than the latter(x2 = 49.138,P ＜ 0.01 ). The older the age was, the higher the rate was(x2 = 770.708, P ＜ 0.01 ). Main clinical manifestation of the patients was depigmentation and pigmentation in skin. Patients with one symptom accounted for 43.30% (265/612), with two symptoms accounted for 56.70% (347/612). Three hundred and seventy drinking water samples were detected, the median of arsenism content was 0.005 mg/L, ranged 0 - 1.660 mg/L. The over-limit rate of arsenic level in the drinking water were 11.62% (43/370). Conclusion Water-born endemic arsenism is mildly prevailing in Shaanxi province, however, great attention should be given to control and monitoring of the disease.