CAJ | 학술논문

目的探讨生活习惯及生理生化因素对主动脉弓钙化(AAC)的影响.方法收集"广州生物库队列研究"第一、二期的研究对象20430名,年龄50～85岁的基线资料,体格检查、实验室检查和胸部X线的AAC诊断结果及详细的问卷调查数据;用logistic回归分析某些生活习惯及生理生化因素与AAC患病率之间的关系.结果 (1)2名高级放射诊断医师独立阅片对AAC诊断符合率为85%,Kappa值为0.68(P<0.01),显示AAC诊断是可靠的;(2)除血压外,男女性在某些生理生化特征上有明显差别(P<0.05);(3)年龄、吸烟、LDL-C及高血压是男女性患AAC的危险因素(P<0.01),其OR值(95%CI):年龄男性为1.11(1.10～1.12),女性1.12(1.12～1.13);吸烟男性为1.31(1.17～1.47),女性1.31(1.09～1.57);LDL-C男性为1.16(1.06～1.27),女性为1.38(1.22～1.56);高血压男性为1.33(1.18～1.50),女性为1.27(1.18～1.38);女性患糖尿病增加患AAC的风险(P<0.001),其OR值(95%CI)为1.38(1.22～1.56).结论年龄、吸烟、高血压、LDL-C是患AAC的危险因素,糖尿病增加女性患AAC的风险.
목적 탐토생활습관급생리생화인소대주동맥궁개화(AAC)적영향.방법 수집"엄주생물고대렬연구"제일、이기적연구대상20430명,년령50～85세적기선자료,체격검사、실험실검사화흉부X선적AAC진단결과급상세적문권조사수거;용logistic회귀분석모사생활습관급생리생화인소여AAC환병솔지간적관계.결과 (1)2명고급방사진단의사독립열편대AAC진단부합솔위85%,Kappa치위0.68(P<0.01),현시AAC진단시가고적;(2)제혈압외,남녀성재모사생리생화특정상유명현차별(P<0.05);(3)년령、흡연、LDL-C급고혈압시남녀성환AAC적위험인소(P<0.01),기OR치(95%CI):년령남성위1.11(1.10～1.12),녀성1.12(1.12～1.13);흡연남성위1.31(1.17～1.47),녀성1.31(1.09～1.57);LDL-C남성위1.16(1.06～1.27),녀성위1.38(1.22～1.56);고혈압남성위1.33(1.18～1.50),녀성위1.27(1.18～1.38);녀성환당뇨병증가환AAC적풍험(P<0.001),기OR치(95%CI)위1.38(1.22～1.56).결론 년령、흡연、고혈압、LDL-C시환AAC적위험인소,당뇨병증가녀성환AAC적풍험.
Objective To explore the impact of lifestyle-related,physiological and biochemical factors on aortic arch calcification(AAC).Methods 20 430 subjects aged 50 to 85 years were included in this study from the first and second recruitment phase of the Guangzhou Biobank Cohort Study.All the subjects received face-to-face interviews to collect detailed information on their socio-demographic background,occupational exposures,living environment,lifestyle,family and personal disease histories,and received a physical examination and tests including 12-lead ECG,chest radiograph,and pulmonary function testing.Each subject was screened for a range of fasting biochemical parameters.Radiographs were reviewed by two senior radiologists.300 radiographs were independently read by the two radiologists to assess agreement using Kappa coefficient.Logistic regression was used to assess the association between life style,physiological and biocheroical factors and AAC.Resuits (1)The rate of agreement on diagnosis for the two radiologists was 85% and Kappa coefficient was 0.68(P<0.01) which showed a moderate agreementbetween the two radiologists.(2) Except hypertension,the subjects were significantly difierent on their lifestyle,physiological and biochemical factors in both men and women(P<0.05).(3)AAC was significantly associated with older age,smoking status,LDL-C,and hypertension(P<0.01)in both genders.Ors(95%CI)indicated the following results:age was 1.11(1.10-1.12) in men and 1.12 (1.12-1.13)in women;smoking as 1.31(1.17-1.47)in men and 1.31(1.09-1.57)in women;LDL-Cas 1.16(1.06-1.27) in men and 1.38(1.22-1.56) in women,hypertension as 1.33(1.18-1.50) in men and 1.27(1.18-1.38) in women.However,diabetes was found to be associated with an increased risk of AAC in women[OR(95%CI)]1.38(1.22-1.56).Conclusion Age,smoking,hypertension and Low-density lipoprotcin level were risk factors to beth genders,on AAC,while diabetes increased the risk of AAC,in women.