CAJ | 학술논문

目的研究涎腺腺样囊性癌MMP-2和MMP-9表达情况，评估其与涎腺腺样囊性癌神经浸润和淋巴结转移的关系。方法选取53例涎腺腺样囊性癌，以抗MMP-2和MMP-9单克隆抗体用Envision法进行免疫组织化学染色和半定量分析。结果 MMP-2和MMP-9在涎腺腺样囊性癌中的表达率分别为67.92％和 79.25％；有神经浸润的腺样囊性癌其MMP-2和MMP-9的表达水平远高于无浸润者(P＜0.05，P＜0.05)；随着MMP-2和MMP-9的表达水平增高，淋巴结转移率也增高(P＜0.05，P＜0.05)。结论提示MMP-2和 MMP-9的高表达与涎腺腺样囊性癌易侵犯神经的特性及发生淋巴结转移密切相关。
목적연구연선선양낭성암MMP-2화MMP-9표체정황，평고기여연선선양낭성암신경침윤화림파 결전이적관계。방법선취53례연선선양낭성암，이항MMP-2화MMP-9단극륭항체용Envision법진행면역 조직화학염색화반정량분석。결과 MMP-2화MMP-9재연선선양낭성암중적표체솔분별위67.92％화 79.25％；유신경침윤적선양낭성암기MMP-2화MMP-9적표체수평원고우무침윤자(P＜0.05，P＜0.05)；수 착MMP-2화MMP-9적표체수평증고，림파결전이솔야증고(P＜0.05，P＜0.05)。결론제시MMP-2화 MMP-9적고표체여연선선양낭성암역침범신경적특성급발생림파결전이밀절상관。
Purpose To study the patterns of the expression of MMP-2 and MMP-9 in human salivary adenoid cystic carcinoma and evaluate the relationship between the expression and nerve invasion and lymph node metastasis. Methods The immunohistochemical location of MMP-2 and MMP-9 was evaluated by using Envision immunoperoxidase technique. Studies were performed in 53 surgical excised specimens. The immunohistochemical staining results were densitometrically semiquantitatived. Results The expressions of MMP-2 and MMP-9 in salivary adenoid cystic carcinoma were 67.92 % and 79.25 % respectively. The MMP-2 and MMP-9 levels in salivary adenoid cystic carcinoma with nerve invasion were much higher than those without invasion(P＜ 0.05, P＜ 0.05 respectively), and the percentage of lymph node metastasis rose with the change of MMP-2 and MMP-9 (P ＜ 0.05, P ＜ 0.05 respectively). Conclusions The results indicate that the rise of MMP-2 and MMP-9 correlate with the nerve invasion and lymph node metastasis.