中国介入影像与治疗学
中國介入影像與治療學
중국개입영상여치료학
CHINESE JOURNAL OF INTERVENTIONAL IMAGING AND THERAPY
2009年
4期
301-304
,共4页
阿霉素脂质体%微波%辐射%VX2肿瘤
阿黴素脂質體%微波%輻射%VX2腫瘤
아매소지질체%미파%복사%VX2종류
Adriamycin liposome%Microwave%Radiation%VX2 tumor
目的 探讨应用微波辐射联合阿霉素脂质体对兔VX2肝肿瘤的治疗作用.方法 将肝脏已成功接种VX2肿瘤的新西兰大白兔随机分成4组,每组8只.A组为肝动脉注入阿霉素碘化油乳剂;B组为注入阿霉素脂质体碘化油乳剂;C组微波辐射联合栓塞阿霉素碘化油乳剂;D组微波辐射联合栓塞阿霉素脂质体碘化油乳剂;4组实验动物于介入术前1d、术后14d行CT肝脏扫描,测量肿瘤大小;术前1d、术后1d、7d行肝功能检查,在微波辐射前、辐射中、辐射后30min、1h测量呼吸频率、心率和体温.术后15d处死动物,全部实验动物均取肿瘤组织及周围组织作组织病理学检查.结果 术前1d各组动物肿瘤体积、肝功能无明显统计学差异.术后14d平均肿瘤体积A组为(6.02±1.21)cm3,B组为(5.74±1.43)cm3,C组为(3.26±0.37)cm3,D组为(1.89±0.14)cm3.各组肝功能检测无明显差异;微波辐射后兔的生命体征稳定,病理学检查组织坏死程度为D组最为明显(P<0.05).结论 经动脉途径应用阿霉素脂质体联合微波辐射抗兔VX2肝肿瘤效果明显,认为微波有助于提高阿霉素脂质体的抗肿瘤效果,联合治疗安全可行.
目的 探討應用微波輻射聯閤阿黴素脂質體對兔VX2肝腫瘤的治療作用.方法 將肝髒已成功接種VX2腫瘤的新西蘭大白兔隨機分成4組,每組8隻.A組為肝動脈註入阿黴素碘化油乳劑;B組為註入阿黴素脂質體碘化油乳劑;C組微波輻射聯閤栓塞阿黴素碘化油乳劑;D組微波輻射聯閤栓塞阿黴素脂質體碘化油乳劑;4組實驗動物于介入術前1d、術後14d行CT肝髒掃描,測量腫瘤大小;術前1d、術後1d、7d行肝功能檢查,在微波輻射前、輻射中、輻射後30min、1h測量呼吸頻率、心率和體溫.術後15d處死動物,全部實驗動物均取腫瘤組織及週圍組織作組織病理學檢查.結果 術前1d各組動物腫瘤體積、肝功能無明顯統計學差異.術後14d平均腫瘤體積A組為(6.02±1.21)cm3,B組為(5.74±1.43)cm3,C組為(3.26±0.37)cm3,D組為(1.89±0.14)cm3.各組肝功能檢測無明顯差異;微波輻射後兔的生命體徵穩定,病理學檢查組織壞死程度為D組最為明顯(P<0.05).結論 經動脈途徑應用阿黴素脂質體聯閤微波輻射抗兔VX2肝腫瘤效果明顯,認為微波有助于提高阿黴素脂質體的抗腫瘤效果,聯閤治療安全可行.
목적 탐토응용미파복사연합아매소지질체대토VX2간종류적치료작용.방법 장간장이성공접충VX2종류적신서란대백토수궤분성4조,매조8지.A조위간동맥주입아매소전화유유제;B조위주입아매소지질체전화유유제;C조미파복사연합전새아매소전화유유제;D조미파복사연합전새아매소지질체전화유유제;4조실험동물우개입술전1d、술후14d행CT간장소묘,측량종류대소;술전1d、술후1d、7d행간공능검사,재미파복사전、복사중、복사후30min、1h측량호흡빈솔、심솔화체온.술후15d처사동물,전부실험동물균취종류조직급주위조직작조직병이학검사.결과 술전1d각조동물종류체적、간공능무명현통계학차이.술후14d평균종류체적A조위(6.02±1.21)cm3,B조위(5.74±1.43)cm3,C조위(3.26±0.37)cm3,D조위(1.89±0.14)cm3.각조간공능검측무명현차이;미파복사후토적생명체정은정,병이학검사조직배사정도위D조최위명현(P<0.05).결론 경동맥도경응용아매소지질체연합미파복사항토VX2간종류효과명현,인위미파유조우제고아매소지질체적항종류효과,연합치료안전가행.
Objective To assess the therapeutic effect of microwave radiation combined with Adriamycin liposome on liver VX2 tumor in rabbits. Methods VX2 tumor pieces were successfully implanted into liver lobes of rabbits with liver tumors formation. All rabbits were divided randomly into 4 groups (each n=8). Group A underwent transcatheter arterial chemoembolization (TACE) with Adriamycin, group B were treated with Adriamycin liposome, group C were treated with microwave radiation combinate with Adriamycin, and group D were treated with microwave radiation combinate with Adriamycin liposome. Spiral CT scans was performed to measure size of liver tumors at 1 day before operation and 14 days after operation, and liver function was tested at 1 day before operation, 1 day and 7 days after operation. Breathing frequency, heart rate and body temperture were measured before microwave radiation processing of microwave radiation, at 30 min after microwave radiation and 1 h after microwave radiation. All experimental animals were scarficed on the 15th day after operation and followed by pathologic and histologic examination of the tumor and after the operation with correlative comparisons. Results There was no significant difference in volumes and liver function among 4 groups at 1 day before operation. At 14 days after operation, the average tumor volume was (6.02±1.21) cm3 in group A, (5.74±1.43) cm3 in group B, (3.26±0.37) cm3 in group C and (1.89±0.14) cm3 in group D. There was no significant difference of liver function among 4 groups. After microwave radiation the rabbit's vital signs were stable. The intratumoral necrosis was more significant in group D than in the others (P<0.05). Conclusion Adriamycin liposome treatment for liver tumor via vascular interventional method combined with microwave radiation can significantly inhibit the growth of liver VX2 tumor in rabbits. Adriamycin liposome is a kind of effective pracputium in interventional chemoembelization, and the united therapy is safe and acceptable.
