CAJ | 학술논문

哺乳动物细胞内有两条蛋白降解途径:泛素.蛋白酶体通路和自噬-溶酶体通路.蛋白酶体由多种蛋白亚单位组成,在降解细胞短寿命蛋白中有重要作用.近来的研究发现蛋白酶体降解系统在细胞信号转导和细胞功能中有重要作用.蛋白酶体功能障碍或失调可能参与某些神经退行性疾病的致病机制.本文综述蛋白酶体在细胞信号转导中的生物学功能和在神经退行性疾病中的可能作用.
포유동물세포내유량조단백강해도경:범소.단백매체통로화자서-용매체통로.단백매체유다충단백아단위조성,재강해세포단수명단백중유중요작용.근래적연구발현단백매체강해계통재세포신호전도화세포공능중유중요작용.단백매체공능장애혹실조가능삼여모사신경퇴행성질병적치병궤제.본문종술단백매체재세포신호전도중적생물학공능화재신경퇴행성질병중적가능작용.
There are two degradation systems in mammalian cells,autophagy/lysosomal pathway and ubiquitin-proteasome pathway.Proteasome is consist of multiple protein subunits and plays important roles in degradation of short-lived cellular proteins.Recent studies reveal that proteasomal degradation system is also involved in signal transduction and regulation of various cellular functions.Dysfunction or dysregulation of proteasomal function may thus be an important pathogenic mechanism in certain neurological disorders.This paper reviews the biological functions of proteasome in signal transduction and its potential roles in neurodegenerative diseases.