CAJ | 학술논문

鲍曼不动杆菌是一种不发酵葡萄糖的革兰阴性球杆菌,近年来临床检出率呈上升趋势,是医院内感染中分离的重要病原菌.鲍曼不动杆菌由于其生存力强、耐药谱广及耐药率高的特点引起了广泛地关注.其耐药机制主要包括产生β-内酰胺酶、青霉素结合蛋白改变、外膜通透性降低和主动外排增强.该文对鲍曼不动杆菌耐β-内酰胺类抗生素机制,尤其是对外膜孔蛋白和主动外排系统机制进行了详细综述.
포만불동간균시일충불발효포도당적혁란음성구간균,근년래림상검출솔정상승추세,시의원내감염중분리적중요병원균.포만불동간균유우기생존력강、내약보엄급내약솔고적특점인기료엄범지관주.기내약궤제주요포괄산생β-내선알매、청매소결합단백개변、외막통투성강저화주동외배증강.해문대포만불동간균내β-내선알류항생소궤제,우기시대외막공단백화주동외배계통궤제진행료상세종술.
Acinetobacter baumannii, a glucose-nonfermentative gram-negative coccobacillus, is an important pathogen isolated in nosocomial infections, and the clinical detection rate has been increasing in recent years. Acinetobacter baumannii attracts widespread attention due to strong viability, broad resistance spectrum and high rate of drug resistance. The resistance mechanisms include the production of β-lactamases, alterations in penicillin-binding proteins, decreased outer membrane permeability and overexpression of active efflux pumps. The mechanisms of Acinetobacter baumannii resistance to β-lactarn antibiotics, especially those of the outer membrane porin and active efflux system are reviewed in this paper.