CAJ | 학술논문

目的:探讨国产注射用比伐卢定和肝素在经皮冠状动脉介入治疗(PCI)术中对血小板功能的影响. 方法:选择36例择期行PCI的患者,术中用肝素(肝索组,n=18)或国产注射用比伐卢定(比伐卢定组,n=18)抗凝.分别在用药前、用药后10 min、用药结束、用药结束后30 min、用药结束后2 h静脉采血,检测二磷酸腺苷诱导的血小板最大聚集率和血浆P选择素水平. 结果:肝素组患者用药后血小板最大聚集率及血浆P选择索水平升高,用药后10 min与用药前比较,差异均有统计学意义(P均<0.05),其余各时间点与用药前比较,差异均无统计学意义(P均>0.05).比伐卢定组患者血小板最大聚集率及血浆P选择素水平,用药后10 min及用药结束与用药前比较均降低(P均<0.05),差异均有统计学意义;用药结束后30 min与用药前比较,差异无统计学意义(P>0.05). 结论:与常规肝素抗凝相比,国产注射用比伐卢定作为抗凝剂应用于PCI术中可以短时间内降低血小板活性、抑制血小板聚集,具有暂时性抗血小板的功能.
목적:탐토국산주사용비벌로정화간소재경피관상동맥개입치료(PCI)술중대혈소판공능적영향. 방법:선택36례택기행PCI적환자,술중용간소(간색조,n=18)혹국산주사용비벌로정(비벌로정조,n=18)항응.분별재용약전、용약후10 min、용약결속、용약결속후30 min、용약결속후2 h정맥채혈,검측이린산선감유도적혈소판최대취집솔화혈장P선택소수평. 결과:간소조환자용약후혈소판최대취집솔급혈장P선택색수평승고,용약후10 min여용약전비교,차이균유통계학의의(P균<0.05),기여각시간점여용약전비교,차이균무통계학의의(P균>0.05).비벌로정조환자혈소판최대취집솔급혈장P선택소수평,용약후10 min급용약결속여용약전비교균강저(P균<0.05),차이균유통계학의의;용약결속후30 min여용약전비교,차이무통계학의의(P>0.05). 결론:여상규간소항응상비,국산주사용비벌로정작위항응제응용우PCI술중가이단시간내강저혈소판활성、억제혈소판취집,구유잠시성항혈소판적공능.
Objective:To investigate the effect of domestic bivalirudin and heparin on platelet function during percutaneous coronary intervention (PCI). Methods:Thirty six selected PCI patients were randomized into two groups, Heparin group (n = 18) and Bivalirudin group (n = 18) , intravenous domestic bivalirudin and heparin were respectively injected as anticoagulants for PCI procedure. Platelet maximum aggregation (PMA) rate induced by adenosine diphosphate and P-selection were measured 10 minutes after the first injection, before PCI procedure, at the end of PCI, and 30 minutes, 2 hours after PCI procedure respectively. Results: In Heparin group, PMA and the level of P-selection were significantly increased at 10 minutes after the injection (P <0. 05 respectively) and then gradually fell back to normal. In Bivalirudin group, PMA and P-selection were significantly decreased 10 minutes after the injection and then maintained the lower level until the end of PCI procedure ( P < 0. 05 respectively) . While for 30 minutes after the injection, both PMA and P-selection returned near the basal level (P > 0.05).Conclusion: Compared with the conventional anticoagulant heparin, bivalirudin could decrease platelet activity and inhibit platelet aggregation at the short period of time during PCI.