国际检验医学杂志
國際檢驗醫學雜誌
국제검험의학잡지
INTERNATIONAL JOURNAL OF LABORATORY MEDICINE
2010年
6期
563-564
,共2页
α1-抗胰蛋白酶%环境污染%实验室技术和方法
α1-抗胰蛋白酶%環境汙染%實驗室技術和方法
α1-항이단백매%배경오염%실험실기술화방법
α1-antitrypsin antitrypain%environmental pollution%Laboratory Techniques and Procedures
目的 观察石油化工企业大气污染对企业职工α1-抗胰蛋白酶(α1-AT)浓度的影响.方法 将石化体检者按工作年限分组,Ⅰ组(<10年)291例,年龄22~35岁,Ⅱ组(10~20年)634例,年龄33~45岁.Ⅲ组(>20年)427例,年龄44～55岁.正常对照组根据石化体检者的分组情况按年龄<35岁、35~45岁、>40岁分组,所有血清样本在全自动生化分析仪七检测α1-AT含量,观察不同组间结果 的差异.结果 Ⅰ组中石化体检者α1-AT结果 为2.58±0.38 g/L,P>0.05,与对照组差异无统计学意义,Ⅱ组和Ⅲ组α1-AT结果 分别为2.02±0.43 g/L和1.72±0.41 g/L,P<0.05,与对照组差异有统计学意义.同时,石化体检者不同工作年限Ⅰ、Ⅱ、Ⅲ组间血清α1-AT结果 差异有统计学意义,P<0.05.而正常对照不同年龄组α1-AT结果 间差异无统计学意义,P>0.05.结论 石油化工厂在进行石油冶炼过程中排放的二氧化氮、烯烃、链烷、醇、羰基等有害物质,对人体的α1-AT含量产生了一定的影响,石油化工企业在积极治理厂区大气环境污染的同时,对职工定期监测α1-AT含量,及时采取一定的治疗手段,对降低肺部疾病的发病率有着重要意义.
目的 觀察石油化工企業大氣汙染對企業職工α1-抗胰蛋白酶(α1-AT)濃度的影響.方法 將石化體檢者按工作年限分組,Ⅰ組(<10年)291例,年齡22~35歲,Ⅱ組(10~20年)634例,年齡33~45歲.Ⅲ組(>20年)427例,年齡44～55歲.正常對照組根據石化體檢者的分組情況按年齡<35歲、35~45歲、>40歲分組,所有血清樣本在全自動生化分析儀七檢測α1-AT含量,觀察不同組間結果 的差異.結果 Ⅰ組中石化體檢者α1-AT結果 為2.58±0.38 g/L,P>0.05,與對照組差異無統計學意義,Ⅱ組和Ⅲ組α1-AT結果 分彆為2.02±0.43 g/L和1.72±0.41 g/L,P<0.05,與對照組差異有統計學意義.同時,石化體檢者不同工作年限Ⅰ、Ⅱ、Ⅲ組間血清α1-AT結果 差異有統計學意義,P<0.05.而正常對照不同年齡組α1-AT結果 間差異無統計學意義,P>0.05.結論 石油化工廠在進行石油冶煉過程中排放的二氧化氮、烯烴、鏈烷、醇、羰基等有害物質,對人體的α1-AT含量產生瞭一定的影響,石油化工企業在積極治理廠區大氣環境汙染的同時,對職工定期鑑測α1-AT含量,及時採取一定的治療手段,對降低肺部疾病的髮病率有著重要意義.
목적 관찰석유화공기업대기오염대기업직공α1-항이단백매(α1-AT)농도적영향.방법 장석화체검자안공작년한분조,Ⅰ조(<10년)291례,년령22~35세,Ⅱ조(10~20년)634례,년령33~45세.Ⅲ조(>20년)427례,년령44～55세.정상대조조근거석화체검자적분조정황안년령<35세、35~45세、>40세분조,소유혈청양본재전자동생화분석의칠검측α1-AT함량,관찰불동조간결과 적차이.결과 Ⅰ조중석화체검자α1-AT결과 위2.58±0.38 g/L,P>0.05,여대조조차이무통계학의의,Ⅱ조화Ⅲ조α1-AT결과 분별위2.02±0.43 g/L화1.72±0.41 g/L,P<0.05,여대조조차이유통계학의의.동시,석화체검자불동공작년한Ⅰ、Ⅱ、Ⅲ조간혈청α1-AT결과 차이유통계학의의,P<0.05.이정상대조불동년령조α1-AT결과 간차이무통계학의의,P>0.05.결론 석유화공엄재진행석유야련과정중배방적이양화담、희경、련완、순、탄기등유해물질,대인체적α1-AT함양산생료일정적영향,석유화공기업재적겁치리엄구대기배경오염적동시,대직공정기감측α1-AT함량,급시채취일정적치료수단,대강저폐부질병적발병솔유착중요의의.
Objective To observe the effect of atmospheric pollution on workers'α1-antitrypsin concentrationb in petrochemical enterprises.Methods During health examination,the workers were indivded into 3 groups according tO the length of job experience.Ⅰ group(<10 years)included 291 cases,aged 22-35 years old,Ⅱ group(10-20 years)included 634 cases,aged 33-45 years old,and Ⅲgroup(>20 years)included 427 cases,aged 44-55 years old.The normal control were individed int different group according to the status of petrochemical workers.,all the serum samples were detected on automatic biochemical analyzer,α1-antitrypsin levels were analyzed between the different groups.Results In group Ⅰ,the α1-AT concentration was 2.58±0.38 g/L(P>0.05)without significant difference compared with control.In group Ⅱ and Ⅲ,the concentration α1-AT were 2.02±0.43 g/L and 1.72±0.41 g/L respectively with significant differences compared with control.And the significant difference existed among the three groups of petrochemical workers..But the sigficant difference did not exist between different group of control people.Conclusion During the process of oil refining,the plants exhausted the polluted gas of nitrogen dioxide,olefins,alkanes,alcohols,carbonyl and other harmful substances,it influenced theα-AT levels of body.It is a good suggestion to decreas the petrochemical pollution,and to monitor the serum concentration of α-AT content among petrochemical workers,it might to reduce the incidence of lung disease of great significance.
