CAJ | 학술논문

目的探讨结合珠蛋白(Hp)基因多态性与2型糖尿病(T2DM)患者糖尿病视网膜病变(DR)发病的关系.方法将317例T2DM患者分为糖尿病无视网膜病变(NDR)组和DR组,并选取100名正常人作为对照(NC)组.采用PCR技术扩增Hp1和Hp2特异的目的片段,分析Hp基因型及糖尿病(DM)病程、尿白蛋白(UA1b)等生化指标与DR的关系.结果 NDR组、DR组和NC组问Hp等位基因和基因型频率比较,均无统计学差异(P>0.05).经Logistic回归分析显示,DM病程和24h UA1b是DR的独立危险因素,Hp可能与DR无相关性.结论 Hp基因多态性可能与DR无相关性,而DM病程和24h UA1b是DR的独立危险因素.
목적 탐토결합주단백(Hp)기인다태성여2형당뇨병(T2DM)환자당뇨병시망막병변(DR)발병적관계.방법 장317례T2DM환자분위당뇨병무시망막병변(NDR)조화DR조,병선취100명정상인작위대조(NC)조.채용PCR기술확증Hp1화Hp2특이적목적 편단,분석Hp기인형급당뇨병(DM)병정、뇨백단백(UA1b)등생화지표여DR적관계.결과 NDR조、DR조화NC조문Hp등위기인화기인형빈솔비교,균무통계학차이(P>0.05).경Logistic회귀분석현시,DM병정화24h UA1b시DR적독립위험인소,Hp가능여DR무상관성.결론 Hp기인다태성가능여DR무상관성,이DM병정화24h UA1b시DR적독립위험인소.
Objective To investigate the association between haptoglobin(Hp) gene polymorphism and the occurrence of diabetic retinopathy in patients with type 2 diabetes mellitus. Methods The 317 type 2 diabetic patients were categorized into two groups: no diabetic retinopathy (NDR) group, diabetic retinopathy (DR) group. In addition, 100 nondiabetic individuals served as control group. The Hp genotypes were determined by PCR-RFLP， Hp genotype frequencies distribution and clinical features were compared among groups. Results There was no significant difference in Hp allele and genotype frequencies distribution among groups. There was no relationship between Hp genotypes and DR (P>0.05). Additionally, logistic regression analysis showed that diabetic duration and 24 hours urinary albumin were independent risk factors for diabetic retinopathy and that the Hp genotype did not have any association with diabetic retinopathy． Conclusion The Hp polymorphism is not associated with DR. But diabetic duration and 24 hours urinary albumin are independent risk factors for diabetic retinopathy.