CAJ | 학술논문

从豆科植物白皮锦鸡儿(Garagana leucophloea Pojark.)地上部分分离到3个黄酮醇类化合物,经理化和波谱分析鉴定为3-0-甲基山奈酚(1)、3-0-甲基槲皮素(2)和槲皮素(3).活性测定表明,1表现出较强的抗细菌活性,对大肠杆菌和番茄疮痂病菌的半抑制浓度分别为9.00 μg/mL和7.42 μg/mL,最低抑制浓度均为12.5μg/mL；而2和3则表现出较强的抗氧化活性,对DPPH还原的半抑制浓度分别为14.39μg/mL和13.64μg／mL;对β-胡萝卜素-亚油酸氧化的半抑制浓度分别为10.26μg／mL和9.87 μg/mL.上述黄酮醇类化合物均为首次从白皮锦鸡儿中分离得到.
종두과식물백피금계인(Garagana leucophloea Pojark.)지상부분분리도3개황동순류화합물,경이화화파보분석감정위3-0-갑기산내분(1)、3-0-갑기곡피소(2)화곡피소(3).활성측정표명,1표현출교강적항세균활성,대대장간균화번가창가병균적반억제농도분별위9.00 μg/mL화7.42 μg/mL,최저억제농도균위12.5μg/mL；이2화3칙표현출교강적항양화활성,대DPPH환원적반억제농도분별위14.39μg/mL화13.64μg／mL;대β-호라복소-아유산양화적반억제농도분별위10.26μg／mL화9.87 μg/mL.상술황동순류화합물균위수차종백피금계인중분리득도.
Three flavonol derrvativea have been isolated from the aerial parts of Caragana leucophloea Pojark.( Leguminosae).By means of physicochemical and 8pectrometric analysis,they were identified as 3-O-methylkaempferol ( 1),3-O-methylquercetin (2),and quercetin (3).Among them,l exhibited the strongest antibacterial activity with its median inhibitory concentration (IC50 ),ralues on Escherichia coli and Ralstonia solanacearum as 9.00 μg/mL and 7.42 μg/mL,respectively,and minimum inhibitory concentration ( MIC) values on tbese two bacteria equally as 12.5 μg/mL.Either 2 or 3 showed stronger antioxidant activity than 1.The IC50 values of 2 and 3 on DPPH reduction were 14.39 μg/mL and 13.64 μg/mL,respectively,and those on β-carotene-linoleic acid oxidation were 10.26 μg/mL and 9.87 μg/mL,respectively.These flavonol derivatives were isolated from this plant species for the first time.<英文关键词>=Key words:Leguminosae ; Caragana leucophloea ; flavonol erivatives ; antimicrobial activity ; antioxidant activity