中华临床医师杂志（电子版）
中華臨床醫師雜誌（電子版）
중화림상의사잡지（전자판）
CHINESE JOURNAL OF CLINICIANS(ELECTRONIC VERSION)
2012年
13期
84-86
,共3页
脓毒症%抗体生成%免疫%细胞%诊断%预后
膿毒癥%抗體生成%免疫%細胞%診斷%預後
농독증%항체생성%면역%세포%진단%예후
Sepsis%Antibody formation%Immunity,cellular%Diagnosis%Prognosis
目的 观察细胞免疫和体液免疫检测指标对脓毒症患者的诊断和预后评估价值.方法 采用回顾性研究,选取144例脓毒症入院患者,根据脓毒症严重程度和不同预后分组,收集患者体液免疫和细胞免疫检查结果,比较体液免疫和细胞免疫各个指标对脓毒症的临床诊断评估价值.对于非正态分布的计量资料进行对数转换.结果 严重脓毒症组患者C3、C4、α2球蛋白水平均明显低于脓毒症组患者[(1.91±0.22)mg/dl vs.(2.02±1.02) mg/dl; (1.25±0.27) mg/dl vs.(1.40±0.31)mg/dl;( 11.75±3.66) mg/dl vs.(14.06±3.07) mg/dl,P均＜0.05].严重脓毒症β2微球蛋白水平高于脓毒症患者(0.86±0.70 vs.0.34±0.15,P＜0.05).死亡组C3水平明显低于生存组患者[(1.90±0.19)mg/dl vs.(1.98±0.18) mg/dl,P＜0.05]；β2微球蛋白水平高于生存组患者(-0.18±0.38 vs.-0.40±0.28,P ＜0.05).Logistic回归分析显示β2微球蛋白是脓毒症死亡的独立危险因子.然而,对于细胞免疫的各个指标,以不同严重程度和不同预后的脓毒症患者分组,结果均未发现有统计学意义.结论 C3、C4、α2球蛋白和β2微球蛋白有可能提示脓毒症病情严重程度,C3和β2微球蛋白具有评价脓毒症预后的潜在价值.
目的 觀察細胞免疫和體液免疫檢測指標對膿毒癥患者的診斷和預後評估價值.方法 採用迴顧性研究,選取144例膿毒癥入院患者,根據膿毒癥嚴重程度和不同預後分組,收集患者體液免疫和細胞免疫檢查結果,比較體液免疫和細胞免疫各箇指標對膿毒癥的臨床診斷評估價值.對于非正態分佈的計量資料進行對數轉換.結果 嚴重膿毒癥組患者C3、C4、α2毬蛋白水平均明顯低于膿毒癥組患者[(1.91±0.22)mg/dl vs.(2.02±1.02) mg/dl; (1.25±0.27) mg/dl vs.(1.40±0.31)mg/dl;( 11.75±3.66) mg/dl vs.(14.06±3.07) mg/dl,P均＜0.05].嚴重膿毒癥β2微毬蛋白水平高于膿毒癥患者(0.86±0.70 vs.0.34±0.15,P＜0.05).死亡組C3水平明顯低于生存組患者[(1.90±0.19)mg/dl vs.(1.98±0.18) mg/dl,P＜0.05]；β2微毬蛋白水平高于生存組患者(-0.18±0.38 vs.-0.40±0.28,P ＜0.05).Logistic迴歸分析顯示β2微毬蛋白是膿毒癥死亡的獨立危險因子.然而,對于細胞免疫的各箇指標,以不同嚴重程度和不同預後的膿毒癥患者分組,結果均未髮現有統計學意義.結論 C3、C4、α2毬蛋白和β2微毬蛋白有可能提示膿毒癥病情嚴重程度,C3和β2微毬蛋白具有評價膿毒癥預後的潛在價值.
목적 관찰세포면역화체액면역검측지표대농독증환자적진단화예후평고개치.방법 채용회고성연구,선취144례농독증입원환자,근거농독증엄중정도화불동예후분조,수집환자체액면역화세포면역검사결과,비교체액면역화세포면역각개지표대농독증적림상진단평고개치.대우비정태분포적계량자료진행대수전환.결과 엄중농독증조환자C3、C4、α2구단백수평균명현저우농독증조환자[(1.91±0.22)mg/dl vs.(2.02±1.02) mg/dl; (1.25±0.27) mg/dl vs.(1.40±0.31)mg/dl;( 11.75±3.66) mg/dl vs.(14.06±3.07) mg/dl,P균＜0.05].엄중농독증β2미구단백수평고우농독증환자(0.86±0.70 vs.0.34±0.15,P＜0.05).사망조C3수평명현저우생존조환자[(1.90±0.19)mg/dl vs.(1.98±0.18) mg/dl,P＜0.05]；β2미구단백수평고우생존조환자(-0.18±0.38 vs.-0.40±0.28,P ＜0.05).Logistic회귀분석현시β2미구단백시농독증사망적독립위험인자.연이,대우세포면역적각개지표,이불동엄중정도화불동예후적농독증환자분조,결과균미발현유통계학의의.결론 C3、C4、α2구단백화β2미구단백유가능제시농독증병정엄중정도,C3화β2미구단백구유평개농독증예후적잠재개치.
Objective To explore the diagnostic and prognostic value of cellular and humoral immunity indexes in sepsis patients.Methods A retrospective analysis was employed.144 sepsis inpatients were selected and divided into different subgroups,such as sepsis and severe sepsis;survivors and non-survivors.All patients' humoral immunity and cellular immunity test results were collected in order to compare the significance of different immune parameters.Measurement data of non-normal distribution was under logarithmic conversion.Results Patients with severe sepsis group had significant lower C3,C4 and α2-globulin level than patients with sepsis group[sever sepsis vs.sepsis:(1.91 ±0.22)mg/dl vs.(2.02 ±1.02)mg/dl;(1.25 ±0.27)mg/dl vs.(1.40 ±0.31)mg/dl;(11.75 ±3.66) mg/dl vs.( 14.06 ± 3.07) mg/dl,P ＜ 0.05 ].Moreover,severe sepsis had significant higher β2-microglobulin levels(0.86 ±0.70 vs.0.34 ±0.15,P ＜0.05).Non-survivors group had significant lower C3 than survival patients [(1.90±0.19) mg/dl vs.(1.98 ± 0.18) mg/dl,P ＜ 0.05] ; β2-microglobulin levels higher than the survival patients ( - 0.18 ± 0.38 vs.- 0.40 ± 0.28,P ＜ 0.05 ).Logistic regression analysis showed that β2-microglobulin was an independent risk factor of sepsis deaths.However,various indicators of cellular immunity in terms of different severity and prognosis in patients with sepsis were not found significant differences.Conclusions C3,C4,α2-globulin and β2-microglobulin could prompt sepsis severity,and C3 and β2-microglobulin could be used to evaluate sepsis prognosis.
