CAJ | 학술논문

本文对不同病期的流行性出血热患者96例进行了血清腺苷脱氨酶(ADA)的检测,结果证实所有患者普遍有血清ADA增高,早在发热期即高于正常值的2～3倍,异常水平保持7～10天.逐日比较ADA与周围血异型淋巴细胞(异淋)百分率变动情况,发现有相应增减的趋势.鉴于异淋是活化了的淋巴细胞,而ADA是淋巴细胞分化过程中不可缺少的酶.初步认为异淋的出现和ADA的增高可能是免疫器官中的淋巴细胞受流行性出血热病毒抗原刺激后发生异常分化和增殖的结果.
본문대불동병기적류행성출혈열환자96례진행료혈청선감탈안매(ADA)적검측,결과증실소유환자보편유혈청ADA증고,조재발열기즉고우정상치적2～3배,이상수평보지7～10천.축일비교ADA여주위혈이형림파세포(이림)백분솔변동정황,발현유상응증감적추세.감우이림시활화료적림파세포,이ADA시림파세포분화과정중불가결소적매.초보인위이림적출현화ADA적증고가능시면역기관중적림파세포수류행성출혈열병독항원자격후발생이상분화화증식적결과.
Serum adenosine deaminase (ADA) was determined in 96 cases of epidemic hemorrhagic fever (EHF) with various degrees of severity.The levels of ADA were found elevated in all patients.Early in the febrile stage of the disease,the ADA levels were 2 to 3 times of normal and sustained for 7 to 10 days.Daily comparison between the ADA levels and the atypical lymphocytes in peripheral blood showed that there was a tendency of parallel increase or decrease of ADA and lpmphocytes.In considering the atypical lymphecytes are the active cells and ADA is an indispensable enzyme during lymphocyte differentiation,we assume that both the appearance of atypical lymphocytes and the elevated ADA levels in EHF reflecting the unusual differentiation and proliferation of lymphocytes resulted from the stimulation of EHF virus.