CAJ | 학술논문

目的探讨伴攻击或暴力行为精神分裂症患者的电生理机制.方法根据诊断标准,对住院及门诊的精神分裂症患者采用修改版外显攻击量表(MOAS)评定其攻击行为,将符合条件的患者分为攻击或暴力行为精神分裂症组(攻击组,n=70)和非攻击或暴力行为精神分裂症组(非攻击组,n＝65),按照年龄、性别等匹配原则收集健康对照组(n=60),使用日本光电公司生产的MEB-9200诱发功能仪对所有受试者进行P300测试.结果 (1)在Cz点上,P3a的潜伏期攻击组[(344.0±33.0)ms]长于非攻击组[(328.3±28.0)ms] (P=0.01),非攻击组又长于健康组[(310.1±24.0)ms],差异均有统计学意义(P＜0.01)；在Fz点上,P3a的潜伏期攻击组[(348.2±30.1)ms]长于非攻击组[(333±28.5)ms],非攻击组又长于健康组[(312.3±25.4)ms],差异均有统计学意义(P＜0.01).(2)在Cz点上,N2’的波幅攻击组[(6.96±7.2)μV]均高于非攻击组[(3.85±5.4)μV]及健康组[(3.6±4.2)μV],差异均有统计学意义(P＜0.05),而非攻击组及健康组间差异无统计学意义(P=0.985).结论伴攻击或暴力行为的精神分裂症患者的事件相关电位P300有其特征性的电生理状态指标改变.
목적 탐토반공격혹폭역행위정신분렬증환자적전생리궤제.방법 근거진단표준,대주원급문진적정신분렬증환자채용수개판외현공격량표(MOAS)평정기공격행위,장부합조건적환자분위공격혹폭역행위정신분렬증조(공격조,n=70)화비공격혹폭역행위정신분렬증조(비공격조,n＝65),안조년령、성별등필배원칙수집건강대조조(n=60),사용일본광전공사생산적MEB-9200유발공능의대소유수시자진행P300측시.결과 (1)재Cz점상,P3a적잠복기공격조[(344.0±33.0)ms]장우비공격조[(328.3±28.0)ms] (P=0.01),비공격조우장우건강조[(310.1±24.0)ms],차이균유통계학의의(P＜0.01)；재Fz점상,P3a적잠복기공격조[(348.2±30.1)ms]장우비공격조[(333±28.5)ms],비공격조우장우건강조[(312.3±25.4)ms],차이균유통계학의의(P＜0.01).(2)재Cz점상,N2’적파폭공격조[(6.96±7.2)μV]균고우비공격조[(3.85±5.4)μV]급건강조[(3.6±4.2)μV],차이균유통계학의의(P＜0.05),이비공격조급건강조간차이무통계학의의(P=0.985).결론 반공격혹폭역행위적정신분렬증환자적사건상관전위P300유기특정성적전생리상태지표개변.
Objective To explore the electrophysiological mechanisms of the schizophrenic patients with aggressive or violent behaviors.Methods Access the aggressive behaviors of schizophrenic patients being treated in hospitals or clinics with the revised MOAS in accordance with the ICD-10 diagnostic criteria,and sort the qualified patients into two groups:the group of aggressive or violent schizophrenia (Aggressive Group,n=70) and the group of non-aggressive or non-violent schizophrenia ( Non-Aggressive Group,n =65 ) ; 60 age- and gendermatched healthy people were collected as Healthy Group.P300 tests were carried out on patients in these three groups with the MEB-9200 Nicolet Bravo Instrument by the Nihon Kohden Corporation.Results ( 1 ) latency P3a of the Aggressive Group on Cz point exceeded that of the Non-Aggressive Group (P =0.01 ),and that of the Non-Aggressive Group exceeded that of the Healthy Group.All these disparities were of statistical significance (P ＜0.01 ).Latency P3a of the Aggressive Group on Fz point exceeds that of the Non-Aggressive Group,and that of the Non-Aggressive Group exceeded that of Healthy Group.All these disparities are also of stafistical significance (P＜0.01).(2)N2' amplitude of the Aggressive Group on Cz point was higher than those of the Non-Aggressive Group and the Healthy Group.This disparity was of statistical significance(P ＜ 0.05 ) and the disparity between the Non-Aggressive Group and the Healthy Group did not have statistical significance (P =0.985 ).Conclusion Characteristic electrophysiological changes exist in the event-related potentials P300 of schizophrenic patients with aggressive or violent behaviors.