CAJ | 학술논문

通过将渗出型年龄相关性黄斑变性(age-related macular degeneration,AMD)患者黄斑区OCT形态学检查及视觉电生理视功能检查相结合,探讨渗出型AMD的形态学改变与视功能改变之间的相互关系.方法选取初次诊断为年龄相关性渗出型AMD的患者渗出组20例(30只眼)以及同年龄段正常对照组15名(30只眼),根据眼底及荧光造影检查将渗出组仅发生玻璃膜疣和脉络膜新生血管膜(CNV)的12只眼归为早期渗出组,并发视网膜下出血及渗出的18只眼归为渗出期组.对三组病人进行黄斑中心凹OCT检查及眼电生理检查.采用单因素方差分析检查结果.结果 (1)黄斑中心凹水平及垂直神经上皮层厚度:早期渗出组较正常组明显增厚(P＜0.05);渗出期组较正常组和早期渗出组明显增厚(P＜0.05).(2)眼电生理检查结果:暗适应ERG,OPS振荡电位以及P-VEP的检查结果表明,早期渗出组已出现了明显的视功能损害;渗出期组的视功能受损较早期渗出组严重.结论渗出型AMD患者视功能的改变合并有视网膜神经上皮层的变厚,渗出期患者的黄斑区形态以及视网膜功能的改变比渗出早期更严重.
통과장삼출형년령상관성황반변성(age-related macular degeneration,AMD)환자황반구OCT형태학검사급시각전생리시공능검사상결합,탐토삼출형AMD적형태학개변여시공능개변지간적상호관계.방법 선취초차진단위년령상관성삼출형AMD적환자삼출조20례(30지안)이급동년령단정상대조조15명(30지안),근거안저급형광조영검사장삼출조부발생파리막우화맥락막신생혈관막(CNV)적12지안귀위조기삼출조,병발시망막하출혈급삼출적18지안귀위삼출기조.대삼조병인진행황반중심요OCT검사급안전생리검사.채용단인소방차분석검사결과.결과 (1)황반중심요수평급수직신경상피층후도:조기삼출조교정상조명현증후(P＜0.05);삼출기조교정상조화조기삼출조명현증후(P＜0.05).(2)안전생리검사결과:암괄응ERG,OPS진탕전위이급P-VEP적검사결과표명,조기삼출조이출현료명현적시공능손해;삼출기조적시공능수손교조기삼출조엄중.결론 삼출형AMD환자시공능적개변합병유시망막신경상피층적변후,삼출기환자적황반구형태이급시망막공능적개변비삼출조기경엄중.
Objective To investigate the relation between configuration and visual function of macular region on exudative age-related macular degeneration (AMD).Methods OCT and visual electrophysiological examination were used in 30 eyes of 15 healthy volunteers and 30 eyes of 20 exudative AMD patients.Patients with exudative AMD were divided into pre-exudative group and exudative group .Results 1.The resuits of OCT showed that,the thickness of retinal neurepithelium layer (in macular region) in the pre-exudative group was significantly thicker than that in the normal group (P＜0.05); and it was also significantly thicker in the exudative group than that in the other groups (P＜0.05).2.The results of visual electrophysiological examination revealed that visual function injury happened in the pre-exudative group,and it was more severe in the exudative AMD group than that in the pre-exudative group.Conelutiuns In exudative AMD,we found the damage of visual function is accompanied by the change of retinal neurepithelium layer's thickness in macular region.The functional damage of vision and the retinal neurepithelium layer's swelling in the exudative group are more serious than that in the pre-exudative group.