CAJ | 학술논문

目的检测增殖细胞核抗原Ki-67抗原在胃癌中的表达情况,分析与胃癌病理特征之间的关系,探讨胃癌的发生、发展及相关淋巴结转移的关系.方法取胃癌标本共88例作为试验组,慢性浅表性胃炎标本16例作为对照组,通过组织芯片技术和免疫组织化学染色法确定检测部位.结果 Ki-67抗原在胃癌中的表达明显高于慢性浅表性胃炎,二者的阳性率分别为89.4%和26.7%,P<0.001,Ki-67抗原在有淋巴结转移的胃癌中的表达明显高于无淋巴结转移者,二者的阳性率分别为92.2%和62.5%,P=0.036.结论 Ki-67抗原在胃癌中高表达,且与胃癌淋巴结转移相关,对胃癌预后有一定意义.
목적 검측증식세포핵항원Ki-67항원재위암중적표체정황,분석여위암병리특정지간적관계,탐토위암적발생、발전급상관림파결전이적관계.방법 취위암표본공88례작위시험조,만성천표성위염표본16례작위대조조,통과조직심편기술화면역조직화학염색법학정검측부위.결과 Ki-67항원재위암중적표체명현고우만성천표성위염,이자적양성솔분별위89.4%화26.7%,P<0.001,Ki-67항원재유림파결전이적위암중적표체명현고우무림파결전이자,이자적양성솔분별위92.2%화62.5%,P=0.036.결론 Ki-67항원재위암중고표체,차여위암림파결전이상관,대위암예후유일정의의.
Objective To examine the expression of Ki-67 antigen in gastric carcinoma, and to evalua-tion the relationship between Ki-67 and clinical and pathological characters of gastric carcinama and participate in the generation, development and metastasis of lymph node of gastric carcinoma. Methods Eighty-eight paraf-fin wax blocks of gastric carcinoma were divided into experiment group. The control group 16 eases of chronic su-perficial gastritis were collected from the samples of duodenum ulcer or gastric ulcer. Ki-67 antigen in gastric carcinoma and chronic superficial gastritis was detected by immunohistochemistry method and tissue mieroarray. Results The expression of Ki-67 antigen in gastric carcinoma was much higher than that in chronie superficial gastritis(89.4% and 26.7% respectively, P < 0.001). The expression of Ki-67 antigen in gastric carcinoma with metastasis ot: lymph node was much higher than that without metastasis (92.2% and 62.5% respectively, P =0.036). Conclusion Since the expression of Ki-67 antigen in gastric carcinoma is very high, and it correlates with metastasis of lymph node of gastrc carcinoma,it can serve as an important mark for the prognosis of gastric carcinoma.