CAJ | 학술논문

目的回顾性分析85例局限期小细胞肺癌三维适形放疗(3D-CRT)联合化疗疗效及生存率,探讨局限期小细胞肺癌的放疗方法.方法 2004年3月至2008年6月经病理或细胞学证实,且进行4个及以上周期化疗联合放疗的局限期小细胞肺癌85例,采用基于CT定位的累及野放疗,6～10 MV X射线,剂量为46～66 Gy,中位剂量50 Gy,1次/d,5次/周,5～7周.结果全组患者完全缓解率36.5％,部分缓解率52.9％,稳定率10.6％；有效率89.4％.全组患者1、2、3年总生存率分别为65.9％、33.8％、15.9％,总中位生存时间18个月.59例患者有治疗失败原因记录,局部复发9例占15.2％,局部复发+远处转移21例占35.6％,远处转移29例占49.2％.结论局限期小细胞肺癌三维适形技术累及野照射疗效较好,需进一步扩大病例数.
목적 회고성분석85례국한기소세포폐암삼유괄형방료(3D-CRT)연합화료료효급생존솔,탐토국한기소세포폐암적방료방법.방법 2004년3월지2008년6월경병리혹세포학증실,차진행4개급이상주기화료연합방료적국한기소세포폐암85례,채용기우CT정위적루급야방료,6～10 MV X사선,제량위46～66 Gy,중위제량50 Gy,1차/d,5차/주,5～7주.결과 전조환자완전완해솔36.5％,부분완해솔52.9％,은정솔10.6％；유효솔89.4％.전조환자1、2、3년총생존솔분별위65.9％、33.8％、15.9％,총중위생존시간18개월.59례환자유치료실패원인기록,국부복발9례점15.2％,국부복발+원처전이21례점35.6％,원처전이29례점49.2％.결론 국한기소세포폐암삼유괄형기술루급야조사료효교호,수진일보확대병례수.
Objective To analyze the therapeutic effect of three-dimensional conformal involvedfield radiotherapy (3D-CRT)combined with chemotherapy on limited disease stage small cell lung cancer (LD-SCLC).Methods The clinical data of 85 patients of LD-SCLC treated with 3D-CRT at the dose of 2 Gy/fraction,5 fractions per week for 5 - 7 weeks,with the median dose of 50 Gy ( 46 - 66 Gy),combined with 4 -8 cycles chemotherapy,64 males and 21 females,aged 29 -76,were collected and analyzed.Results The complete remission rate,partial remission rate,stability rate,and total effective rate were 36.5％,52.9％,10.6％,and 89.4％,respectively.The median survival time was 18 months,with the 1-,2-,and 3-year overall survival rates of 65.9％,33.8％,and 15.9％,respectively.The local recurrence rate,distant metastasis rate,and local recurrence + distant metastasis rate were 15.2％ (9/85),49.2％ (29/85),and 35.6％ (21/85),respectively.Body weight,response to therapy,cycles for chemotherapy,and concurrent chemo-radiotherapy were all independent prognostic factors for LD-SCLC.Cox muhivariable regression was used to analyze the prognostic factors.Conclusions Involved-field radiotherapy is effective for LD-SCLC.Distance metastasis is the main cause of treatment failure.