CAJ | 학술논문

过去10年,我们对移植免疫排斥机制的理解有了很大提高.在一些同种异体器官移植联合造血干细胞移植的病例,不用免疫抑制剂治疗,受体对移植物仍然保持长期免疫耐受,有作者把这一耐受现象归功于联合了造血干细胞移植.本文就从对这些案例的分析出发,回顾同种异体器官移植后供体特异性移植耐受形成的理论基础和历史沿革,最后阐明供体特异性移植耐受与造血干细胞移植之间并没有直接联系.
과거10년,아문대이식면역배척궤제적리해유료흔대제고.재일사동충이체기관이식연합조혈간세포이식적병례,불용면역억제제치료,수체대이식물잉연보지장기면역내수,유작자파저일내수현상귀공우연합료조혈간세포이식.본문취종대저사안례적분석출발,회고동충이체기관이식후공체특이성이식내수형성적이론기출화역사연혁,최후천명공체특이성이식내수여조혈간세포이식지간병몰유직접련계.
Our understanding of the immunological mechanisms of rejection has greatly improved over the past 10 years. The allografts have maintained long survival without immunosuppressive treatment in the several organ-transplant recipients combined with hematopoietic stem cell transplantation. The authors attributed the successful outcome to the cotransplantation of donor stem cells. The review will analyze firstly conditions of the recipients, and then review the theoretical basis and history regarding donor-specific tolerance of allograft, and it will also clarify that there is no direct link between the donor-specific transplantation tolerance and hematopoietic stem cell transplantation.