北京医学
北京醫學
북경의학
BEIJING MEDICAL JOURNAL
2010年
1期
28-30
,共3页
丁湘彧%胡秀玲%时广利%历学军%荣长利%宋长兴
丁湘彧%鬍秀玲%時廣利%歷學軍%榮長利%宋長興
정상욱%호수령%시엄리%력학군%영장리%송장흥
肺癌%肺结核%胃泌素释放肽前体%神经元特异性烯醇化酶%癌胚抗原%腺苷脱氨酶
肺癌%肺結覈%胃泌素釋放肽前體%神經元特異性烯醇化酶%癌胚抗原%腺苷脫氨酶
폐암%폐결핵%위비소석방태전체%신경원특이성희순화매%암배항원%선감탈안매
Lung%cancer%Pulmonary%tuberculosis%pro-GRP%NSE%CEA%ADA
目的 探讨血清胃泌素释放肽前体(pro-GRP)、神经元特异性烯醇化酶(NSE)、癌胚抗原(CEA)、腺苷脱氨酶(ADA)的检测在肺癌和肺结核鉴别诊断中的临床应用价值.方法 采用ELISA法检测120例肺癌患者、55例肺结核患者和50例正常对照者血清中pro-GRP、NSE和CEA的水平,应用全自动生化分析仪检测血清中ADA的水平.结果 肺癌患者血清中NSE、pro-GRP、CEA的水平分别为(29.5±13.8)ng/ml、(169.2±79.8)pg/ml、(28.6±11.7)ng/ml,均明显高于肺结核组(P<0.01);NSE、pro-GRP在小细胞肺癌中的水平[(39.3±13.7)ng/ml,(291.2±217.5)pg/ml]明显高于腺癌[(16.9±7.2)ng/ml,(79.2±48.1)pg/ml]和鳞癌[(15.2±5.3)ng/ml,(81.6±62.1)pg/ml](P<0.01);CEA在腺癌中的水平为(47.2±20.5)ng/ml,明显高于鳞癌[(21.5±9.8)ng/ml]和小细胞肺癌[(18.6±7.5)ng/ml](P<0.01).肺结核患者血清中ADA的水平明显高于肺癌患者(P<0.01).结论 血清pro-GRP、NSE、CEA、ADA对于肺癌和肺结核的鉴别诊断有一定的临床意义.NSE、pro-GRP二者可作为联合检测小细胞肺癌的标志物组合.
目的 探討血清胃泌素釋放肽前體(pro-GRP)、神經元特異性烯醇化酶(NSE)、癌胚抗原(CEA)、腺苷脫氨酶(ADA)的檢測在肺癌和肺結覈鑒彆診斷中的臨床應用價值.方法 採用ELISA法檢測120例肺癌患者、55例肺結覈患者和50例正常對照者血清中pro-GRP、NSE和CEA的水平,應用全自動生化分析儀檢測血清中ADA的水平.結果 肺癌患者血清中NSE、pro-GRP、CEA的水平分彆為(29.5±13.8)ng/ml、(169.2±79.8)pg/ml、(28.6±11.7)ng/ml,均明顯高于肺結覈組(P<0.01);NSE、pro-GRP在小細胞肺癌中的水平[(39.3±13.7)ng/ml,(291.2±217.5)pg/ml]明顯高于腺癌[(16.9±7.2)ng/ml,(79.2±48.1)pg/ml]和鱗癌[(15.2±5.3)ng/ml,(81.6±62.1)pg/ml](P<0.01);CEA在腺癌中的水平為(47.2±20.5)ng/ml,明顯高于鱗癌[(21.5±9.8)ng/ml]和小細胞肺癌[(18.6±7.5)ng/ml](P<0.01).肺結覈患者血清中ADA的水平明顯高于肺癌患者(P<0.01).結論 血清pro-GRP、NSE、CEA、ADA對于肺癌和肺結覈的鑒彆診斷有一定的臨床意義.NSE、pro-GRP二者可作為聯閤檢測小細胞肺癌的標誌物組閤.
목적 탐토혈청위비소석방태전체(pro-GRP)、신경원특이성희순화매(NSE)、암배항원(CEA)、선감탈안매(ADA)적검측재폐암화폐결핵감별진단중적림상응용개치.방법 채용ELISA법검측120례폐암환자、55례폐결핵환자화50례정상대조자혈청중pro-GRP、NSE화CEA적수평,응용전자동생화분석의검측혈청중ADA적수평.결과 폐암환자혈청중NSE、pro-GRP、CEA적수평분별위(29.5±13.8)ng/ml、(169.2±79.8)pg/ml、(28.6±11.7)ng/ml,균명현고우폐결핵조(P<0.01);NSE、pro-GRP재소세포폐암중적수평[(39.3±13.7)ng/ml,(291.2±217.5)pg/ml]명현고우선암[(16.9±7.2)ng/ml,(79.2±48.1)pg/ml]화린암[(15.2±5.3)ng/ml,(81.6±62.1)pg/ml](P<0.01);CEA재선암중적수평위(47.2±20.5)ng/ml,명현고우린암[(21.5±9.8)ng/ml]화소세포폐암[(18.6±7.5)ng/ml](P<0.01).폐결핵환자혈청중ADA적수평명현고우폐암환자(P<0.01).결론 혈청pro-GRP、NSE、CEA、ADA대우폐암화폐결핵적감별진단유일정적림상의의.NSE、pro-GRP이자가작위연합검측소세포폐암적표지물조합.
Objective To evaluate the clinical significance of pro-GRP,NSE,CEA,ADA in differential diagnosis of lung cancer and pulmonary tuberculosis. Methods The level of pro-GRP,NSE,CEA in serum of 120 patients with lung cancer,55 patients with pulmonary tuberculosis and 50 controls were detected by ELISA. The level of ADA in serum was detected by autobiochemical analysis. Results The level of NSE,pro-GRP,CEA [(29.5±13.8)ng/ml, (169.2±79.8)pg/ml, (28.6±11.7)ng/ml]in patients with lung cancer were higher than those of patients with pulmonary tu-berculosis(P < 0.01).The level of the NSE and pro-GRP in patients with small cell lung cancer were higher than those of other subtypes of lung cancers (P < 0.01).The level of the CEA in patients with adenocarcinoma was higher than that of other subtypes of lung cancers (P < 0.01).The level of ADA in patients with pulmonary tuberculosis was higher than that of patients with lung cancer (P < 0.01). Conclusions The detection of pro-GRP,NSE,CEA and ADA in serum are of clinical significance in differential diagnosis of lung cancer and pulmonary tuberculosis. Combination of NSE and pro-GRP is economic in detecting small cell lung cancer.
